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    Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

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    Lucas_Dalton Trans_MS_accepted.pdf (757.1Kb)
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    Publication date
    2016-04
    Author
    Lucas, S.J.
    Lord, Rianne M.
    Basri, A.M.
    Allison, Simon J.
    Phillips, Roger M.
    Blacker, A.J.
    McGowan, P.C.
    Keyword
    Anti-cancer activity; Cytotoxicity; Cp* complexes
    Rights
    © 2016 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.
    URI
    http://hdl.handle.net/10454/9489
    Version
    Accepted manuscript
    Citation
    Lucas SJ, Lord RM, Basri AM, Allison SJ, Phillips RM, Blacker AJ and McGowan PC (2016) Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes [Communication]. Dalton Transactions. 45(16): 6812.
    Link to publisher’s version
    http://dx.doi.org/10.1039/C6DT00186F
    Type
    Article
    Collections
    Life Sciences Publications

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