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dc.contributor.authorThroup, Adam E.*
dc.contributor.authorPatterson, Laurence H.*
dc.contributor.authorSheldrake, Helen M.*
dc.date.accessioned2016-09-28T11:37:49Z
dc.date.available2016-09-28T11:37:49Z
dc.date.issued2016-09
dc.identifier.citationThroup A, Patterson LH and Sheldrake HM (2016) Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicylolactones. Organic and Biomolecular Chemistry. 40(14): 9554-9559.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9488
dc.descriptionYesen_US
dc.description.abstractFused cyclobutanes are found in a range of natural products and formation of these motifs in a straightforward and easy manner represents an interesting synthetic challenge. To this end we investigated an intramolecular variant of the thermal enamine [2 + 2] cyclisation, developing a diastereoselective intramolecular enamine [2 + 2] cyclisation furnishing δ lactone and lactam fused cyclobutenes in good yield and excellent diastereoselectivity.en_US
dc.description.sponsorshipThe work was funded by Yorkshire Cancer Researchen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1039/C6OB01661Hen_US
dc.rights© 2016 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en_US
dc.subjectCyclobutanes; Thermal enamine; Diastereoselective intramolecular enamine; Lactone; Lactam; Cyclobutenesen_US
dc.titleIntramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactonesen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-09-15
dc.date.application2016-09-20
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-07-25T15:00:45Z


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