Cytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosis
dc.contributor.author | Lord, Rianne M. | * |
dc.contributor.author | Allison, Simon J. | * |
dc.contributor.author | Rafferty, K. | * |
dc.contributor.author | Ghandhi, L. | * |
dc.contributor.author | Pask, C.M. | * |
dc.contributor.author | McGowan, P.C. | * |
dc.date.accessioned | 2016-09-28T11:00:17Z | |
dc.date.available | 2016-09-28T11:00:17Z | |
dc.date.issued | 2016-09-07 | |
dc.identifier.citation | Lord RM, Allison SJ, Rafferty K, Ghandi L, Pask CM and McGowan PC (2016) Cytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosis. Dalton Transactions. 45: 13196-13203. | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/9487 | |
dc.description | yes | en_US |
dc.description.abstract | This report presents the first known p-cymene ruthenium quinaldamide complexes which are stabilised by a hydrogen-bridging atom, [{(p-cym)RuIIX(N,N)}{H+}{(N,N)XRuII(p-cym)}][PF6] (N,N = functionalised quinaldamide and X = Cl or Br). These complexes are formed by a reaction of [p-cymRu(μ-X)2]2 with a functionalised quinaldamide ligand. When filtered over NH4PF6, and under aerobic conditions the equilibrium of NH4PF6 ⇔ NH3 + HPF6 enables incorporation of HPF6 and the stabilisation of two monomeric ruthenium complexes by a bridging H+, which are counter-balanced by a PF6 counterion. X-ray crystallographic analysis is presented for six new structures with O⋯O distances of 2.420(4)–2.448(15) Å, which is significant for strong hydrogen bonds. Chemosensitivity studies against HCT116, A2780 and cisplatinresistant A2780cis human cancer cells showed the ruthenium complexes with a bromide ancillary ligand to be more potent than those with a chloride ligand. The 4’-fluoro compounds show a reduction in potency for both chloride and bromide complexes against all cell lines, but an increase in selectivity towards cancer cells compared to non-cancer ARPE-19 cells, with a selectivity index >1. Mechanistic studies showed a clear correlation between IC50 values and induction of cell death by apoptosis | en_US |
dc.language.iso | en | en_US |
dc.rights | © 2016 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy. | |
dc.subject | p-cymene ruthenium quinaldamide complexes; Hydrogen bridged; Chemotherapy; Anti-cancer agents | en_US |
dc.title | Cytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosis | en_US |
dc.status.refereed | yes | en_US |
dc.date.Accepted | 2016-07-01 | |
dc.date.application | 2016-07-01 | |
dc.type | Article | en_US |
dc.type.version | Accepted manuscript | en_US |
dc.identifier.doi | https://doi.org/10.1039/c6dt01464j | |
refterms.dateFOA | 2018-07-25T14:31:59Z |