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dc.contributor.authorZhang, K.*
dc.contributor.authorFahr, A.*
dc.contributor.authorAbraham, M.H.*
dc.contributor.authorAcree, W.E. Jr.*
dc.contributor.authorTobin, Desmond J.*
dc.contributor.authorLiu, Xiangli*
dc.date.accessioned2016-09-21T17:20:47Z
dc.date.available2016-09-21T17:20:47Z
dc.date.issued2015-10-15
dc.identifier.citationZhang K, Fahr A, Abraham MH, Acree WE, Jr, Tobin DJ and Liu, X (2015) Comparison of lipid membrane-water partitioning with various organic solvent-water partitions of neutral species and ionic species: Uniqueness of cerasome as a model for the stratum corneum in partition processes. International journal of Pharmaceutics. 494(1): 1-8.
dc.identifier.urihttp://hdl.handle.net/10454/9426
dc.descriptionYesen
dc.description.abstractLipid membrane-water partitions (e.g., immobilized artificial membrane systems where the lipid membrane is a neutral phospholipid monolayer bound to gel beads) were compared to various organic solvent-water partitions using linear free energy relationships. To this end, we also measured the retention factors of 36 compounds (including neutral and ionic species) from water to liposomes made up of 3-sn-phosphatidylcholine and 3-sn-phosphatidyl-l-serine (80:20, mol/mol), employing liposome electrokinetic chromatography in this work. The results show that lipid membranes exhibit a considerably different chemical environment from those of organic solvents. For both neutral species and ionic species, partitions into the more polar hydroxylic solvents are chemically closer to partition into the lipid membrane as compared to partitions into the less polar hydroxylic solvents and into aprotic solvents. This means that solutes partition into the polar parts of lipid membranes, regardless of whether they are charged or not. In addition, cerasome (i.e., liposome composed mainly of stratum corneum lipids) was compared with regular phospholipid liposomes as a possible model for human stratum corneum in partitions. It was found that the cerasome-water partition exhibits a better chemical similarity to skin permeation. This is probably due to the unique structures of ceramides that occur in cerasome and in the stratum corneum lipid domain. We further show that membranes in membrane-water partitions exhibit very different properties.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.ijpharm.2015.08.010
dc.rights(c) 2015 Elsevier. Full-text reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.subjectIonic species
dc.subject; Lekc
dc.subject; Lfer
dc.subject; Liposomes
dc.subject; Partition
dc.subject; Physicochemical properties
dc.titleComparison of lipid membrane-water partitioning with various organic solvent-water partitions of neutral species and ionic species: Uniqueness of cerasome as a model for the stratum corneum in partition processes
dc.date.Accepted2015-08-03
dc.date.application2015-08-06
dc.typeArticle
dc.type.versionAccepted Manuscripten
refterms.dateFOA2018-07-25T14:30:23Z


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