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    Buddlejol, a new alpha-chymotrypsin inhibitor from Buddleja asiatica

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    Publication date
    2015
    Author
    Khan, F.A.
    Khan, N.M.
    Khan, H.U.
    Khan, S.
    Ali, N.
    Ahmad, S.
    Maitland, Derek J.
    Keyword
    Buddleja asiatica
    ; Ethyl acetate soluble fraction
    ; Buddlejol
    ; Cytotoxic activity
    ; Chymotrypsin inhibition
    ; Chemical-constituents
    ; Medicinal-plants
    ; Mechanism
    ; Elastase
    ; Tobacco
    ; China
    ; Lour
    Show allShow less
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Buddlejol (1), a new sterol, has been isolated from the ethyl acetate soluble fraction of the antispasmodic plant Buddleja asiatica along with stigmasterol (2), lignoceric acid (3), taraxerol (4) and alpha-amyrin (5), respectively. The structure of Buddlejol (1) was established as (24S)-stigmast-5,22-diene-7 beta-ethoxy-3 beta-ol by spectral analysis and comparison with closely related structures. Buddlejol revealed to be a competitive inhibitor of chymotrypsin with the Ki value of 10.60 A mu M as indicated by Lineweaver-Burk and Dixon plots and their re-plots against its chymotrypsin inhibition assay, while the other compounds showed less inhibitory potential. The bioassay-guided isolation was stimulated by the preliminary cytotoxic screening of various fractions of B. asiatica.
    URI
    http://hdl.handle.net/10454/9366
    Version
    No full-text available in the repository
    Citation
    Khan FA, Khan NM, Khan HU et al (2015) Buddlejol, a new alpha-chymotrypsin inhibitor from Buddleja asiatica. Medicinal Chemistry Research. 24(3): 980-986.
    Link to publisher’s version
    http://dx.doi.org/10.1007/s00044-014-1192-9
    Type
    Article
    Collections
    Life Sciences Publications

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