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dc.contributor.authorFatokun, Amos A.*
dc.contributor.authorTome, M.*
dc.contributor.authorSmith, R.A.*
dc.contributor.authorDarlington, L.G.*
dc.contributor.authorStone, T.W.*
dc.date.accessioned2016-09-21T17:16:40Z
dc.date.available2016-09-21T17:16:40Z
dc.date.issued2015-12
dc.identifier.citationFatokun AA, Tome M, Smith RA et al (2015) Protection by the flavonoids quercetin and luteolin against peroxide- or menadione-induced oxidative stress in MC3T3-E1 osteoblast cells. Natural Product Research. 29(12): 1127-1132.
dc.identifier.urihttp://hdl.handle.net/10454/9343
dc.descriptionNo
dc.description.abstractPotential protective effects of the flavonoids quercetin and luteolin have been examined against the oxidative stress of MC3T3-E1 osteoblast-like cells. Although hydrogen peroxide and menadione reduced cell viability, the toxicity was prevented by desferrioxamine or catalase but not superoxide dismutase, suggesting the involvement of hydrogen peroxide in both cases. Quercetin and luteolin reduced the oxidative damage, especially that caused by hydrogen peroxide. When cultures were pre-incubated with quercetin or luteolin, protection was reduced or lost. Protection was also reduced when a 24 h pre-incubation with the flavonoids was followed by exposure to menadione alone. Pretreating cultures with luteolin impaired protection by quercetin, whereas quercetin pretreatment did not affect protection by luteolin. It is concluded that quercetin and luteolin suppress oxidative damage to MC3T3-E1 cells, especially caused by peroxide. The reduction in protection by pretreatment implies a down-regulation of part of the toxic transduction pathway.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1080/14786419.2014.980252
dc.subject3T3 Cells
dc.subject; Animals
dc.subject; Hydrogen peroxide
dc.subject; Luteolin
dc.subject; Mice
dc.subject; Osteoblasts
dc.subject; Oxidative stress
dc.subject; Quercetin
dc.subject; Vitamin K 3
dc.subject; Bone
dc.subject; Flavonoids
dc.subject; Luteolin
dc.subject; Osteoblasts
dc.subject; Oxidative stress
dc.subject; Quercetin
dc.titleProtection by the flavonoids quercetin and luteolin against peroxide- or menadione-induced oxidative stress in MC3T3-E1 osteoblast cells
dc.status.refereedYes
dc.date.Accepted2014-10-21
dc.date.application2014-11-26
dc.typeArticle
dc.type.versionNo full-text available in the repository


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