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dc.contributor.authorAlasmary, Fatmah A.S.*
dc.contributor.authorSnelling, Anna M.*
dc.contributor.authorZain, M.E.*
dc.contributor.authorAlafeefy, A.M.*
dc.contributor.authorAwaad, A.S.*
dc.contributor.authorKarodia, Nazira*
dc.date.accessioned2016-09-21T17:14:28Z
dc.date.available2016-09-21T17:14:28Z
dc.date.issued2015
dc.identifier.citationAlasmary FAS, Snelling AM, Zain ME et al (2015) Synthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents. Molecules. 20(8): 15206-15223.
dc.identifier.urihttp://hdl.handle.net/10454/9303
dc.descriptionNo
dc.description.abstractA library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depended on the substituents attached to the bicyclic heterocycle. In particular, some compounds displayed antibacterial activity against two methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) comparable to the widely-used drug ciprofloxacin. The compounds have some common features; three possess 5-halo substituents; two are derivatives of (S)-2-ethanaminebenzimidazole; and the others are derivatives of one 2-(chloromethyl)-1H-benzo[d]imidazole and (1H-benzo[d]imidazol-2-yl)methanethiol. The results from the antifungal screening were also very interesting: 23 compounds exhibited potent fungicidal activity against the selected fungal strains. They displayed equivalent or greater potency in their MIC values than amphotericin B. The 5-halobenzimidazole derivatives could be considered promising broad-spectrum antimicrobial candidates that deserve further study for potential therapeutic applications.
dc.relation.isreferencedbyhttp://dx.doi.org/10.3390/molecules200815206
dc.subjectBenzimidazole
dc.subject; Heterocycle
dc.subject; Antibacterial activity
dc.subject; Antifungal activity
dc.subject; Resistance
dc.subject; Gram-negative
dc.subject; Gram-positive
dc.subject; Microwave-assisted synthesis
dc.subject; Antiviral activity
dc.subject; Design
dc.subject; Complexes
dc.titleSynthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text available in the repository


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