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    Compressive forces of cell induced longitudinal deformation to the liquid crystal surface

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    Publication date
    2015
    Author
    Soon, Chin Fhong
    Tee, K.S.
    Youseffi, Mansour
    Denyer, Morgan C.T.
    Keyword
    Compressive forces; Keratinocyte; Deformation; Liquid crystal
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The ability of a cell to contract plays an important role in determining the ability of the cell to migrate, proliferate and associating with other cells. The transduction of the force in soft substrate such as the liquid crystal surface is a method proposed to study the traction forces of single cells. In this work, finite element method was used to study the compressive forces induced by the keratinocyte to the liquid crystal surface via the anchorage of focal contacts. The constitutive finite element model of the liquid crystal-focal contacts was established. The stress and displacement were analyzed using linear static stress analysis for a quiescent cell. The data for lateral displacements obtained from the experiment were provided as inputs to develop the model and verified through the output acquired for both simulation and experiment. The simulation results indicated that the cell compressive stresses were in the range of 14.93 ± 1.9 nN/μm2 per focal contact. Based on the result obtained, it was suggested to model focal contact-liquid crystal interface with a compressive model that can better approximate the mechanism observed
    URI
    http://hdl.handle.net/10454/9226
    Version
    No full-text available in the repository
    Citation
    Soon CF, Tee KS, Youseffi M et al (2015) Compressive forces of cell induced longitudinal deformation to the liquid crystal surface. ARPN Journal of Engineering and Applied Sciences. 10(18): 8473-8478.
    Link to publisher’s version
    http://www.arpnjournals.org/jeas/research_papers/rp_2015/jeas_1015_2747.pdf
    Type
    Article
    Collections
    Engineering and Informatics Publications

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