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dc.contributor.authorBarz, T.*
dc.contributor.authorLoffler, V.*
dc.contributor.authorArellano-Garcia, Harvey*
dc.contributor.authorWozny, G.*
dc.date.accessioned2016-09-21T09:33:21Z
dc.date.available2016-09-21T09:33:21Z
dc.date.issued2010
dc.identifier.citationBarz T, Loffler V, Arellano-Garcia H et al (2010) Optimal determination of steric mass action model parameters for beta-lactoglobulin using static batch experiments. Journal of Chromatography A. 1217(26): 4267-4277.
dc.identifier.urihttp://hdl.handle.net/10454/9039
dc.descriptionNo
dc.description.abstractIn this work, parameters of the steric mass-formalism SMA are optimally ascertained for a reliable determination of the adsorption isotherms of beta-lactoglobulin A and B under non-isocratic conditions. For this purpose, static batch experiments are used in contrast to the protocols based on different experimental steps, which use a chromatographic column. It is shown that parameters can already be determined for a small number of experiments by using a systematic procedure based on optimal model-based experimental design and an efficient NLP-solver. The in different works observed anti-Langmuir shape of the isotherm for small concentrations of beta-lactoglobulin A was corroborated. Moreover, we also found indications for a porosity variation with changing protein concentrations.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.chroma.2010.04.001
dc.subjectAdsorption
dc.subject; Chromatography
dc.subject; Lactoglobulins
dc.subject; Models
dc.subject; Static electricity
dc.subject; Stereoisomerism
dc.subject; Thermodynamics; REF 2014
dc.titleOptimal determination of steric mass action model parameters for beta-lactoglobulin using static batch experiments
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository


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