Stabilisation of metastable polymorphs: the case of paracetamol form III
| dc.contributor.author | Telford, Richard | * |
| dc.contributor.author | Seaton, Colin C. | * |
| dc.contributor.author | Clout, A. | * |
| dc.contributor.author | Buanz, A.B.M. | * |
| dc.contributor.author | Gaisford, S. | * |
| dc.contributor.author | Williams, G.R. | * |
| dc.contributor.author | Prior, T.J. | * |
| dc.contributor.author | Okoye, C.H. | * |
| dc.contributor.author | Munshi, Tasnim | * |
| dc.contributor.author | Scowen, Ian J. | * |
| dc.date.accessioned | 2016-09-07T13:45:26Z | |
| dc.date.available | 2016-09-07T13:45:26Z | |
| dc.date.issued | 2016 | |
| dc.identifier.citation | Telford R, Seaton CC, Clout A et al (2016) Stabilisation of metastable polymorphs: the case of paracetamol form III. Chemical Communications. Accepted for publication. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10454/8921 | |
| dc.description | Yes | en_US |
| dc.description.abstract | The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph. | en_US |
| dc.language.iso | en | en_US |
| dc.relation.isreferencedby | http://dx.doi.org/10.1039/C6CC05006A | en_US |
| dc.rights | (c) 2016 The Authors. This is an Open Access article licensed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/) | en_US |
| dc.subject | Metastable polymorphs; Paracetamol form III; Air-stable formulation; Melt synthesis; Melt crystallisation | en_US |
| dc.title | Stabilisation of metastable polymorphs: the case of paracetamol form III | en_US |
| dc.status.refereed | Yes | en_US |
| dc.date.Accepted | 2016-08-05 | |
| dc.date.application | 2016-08-05 | |
| dc.type | Article | en_US |
| dc.type.version | published version paper | en_US |
| dc.description.publicnotes | This article is part of themed collection: Pharmaceutical Solids. | en_US |
| refterms.dateFOA | 2018-07-25T14:07:36Z |
