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dc.contributor.authorTelford, Richard*
dc.contributor.authorSeaton, Colin C.*
dc.contributor.authorClout, A.*
dc.contributor.authorBuanz, A.B.M.*
dc.contributor.authorGaisford, S.*
dc.contributor.authorWilliams, G.R.*
dc.contributor.authorPrior, T.J.*
dc.contributor.authorOkoye, C.H.*
dc.contributor.authorMunshi, Tasnim*
dc.contributor.authorScowen, Ian J.*
dc.date.accessioned2016-09-07T13:45:26Z
dc.date.available2016-09-07T13:45:26Z
dc.date.issued2016
dc.identifier.citationTelford R, Seaton CC, Clout A et al (2016) Stabilisation of metastable polymorphs: the case of paracetamol form III. Chemical Communications. Accepted for publication.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8921
dc.descriptionYesen_US
dc.description.abstractThe design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.en_US
dc.language.isoenen_US
dc.rights(c) 2016 The Authors. This is an Open Access article licensed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/)en_US
dc.subjectMetastable polymorphs; Paracetamol form III; Air-stable formulation; Melt synthesis; Melt crystallisationen_US
dc.titleStabilisation of metastable polymorphs: the case of paracetamol form IIIen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-08-05
dc.date.application2016-08-05
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
dc.description.publicnotesThis article is part of themed collection: Pharmaceutical Solids.en_US
dc.identifier.doihttps://doi.org/10.1039/C6CC05006A
refterms.dateFOA2018-07-25T14:07:36Z


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