Stabilisation of metastable polymorphs: the case of paracetamol form III

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2016Author
Telford, RichardSeaton, Colin C.
Clout, A.
Buanz, A.B.M.
Gaisford, S.
Williams, G.R.
Prior, T.J.
Okoye, C.H.
Munshi, Tasnim
Scowen, Ian J.
Keyword
Metastable polymorphsParacetamol form III
Air-stable formulation
Melt synthesis
Melt crystallisation
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(c) 2016 The Authors. This is an Open Access article licensed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/)Peer-Reviewed
YesOpen Access status
openAccessAccepted for publication
2016-08-05
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The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.Version
Published versionCitation
Telford R, Seaton CC, Clout A et al (2016) Stabilisation of metastable polymorphs: the case of paracetamol form III. Chemical Communications. Accepted for publication.Link to Version of Record
https://doi.org/10.1039/C6CC05006AType
ArticleNotes
This article is part of themed collection: Pharmaceutical Solids.ae974a485f413a2113503eed53cd6c53
https://doi.org/10.1039/C6CC05006A