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    Effect of Transforming Growth Factor-β3 on mono and multilayer chondrocytes

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    Publication date
    2016-07
    Author
    Sefat, Farshid
    Youseffi, Mansour
    Khaghani, Seyed A.
    Soon, Chin Fhong
    Javid, Farideh A.
    Keyword
    Cell length; Cell proliferation; Model wound closure assay; Primary chondrocyte multilayer; TGF-β3
    Rights
    © 2016 Elsevier, Ltd. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    Peer-Reviewed
    Yes
    
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    Abstract
    Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. Transforming growth factor-beta (TGF-β), a cytokine superfamily, regulates cell function, including differentiation and proliferation. Although the function of the TGF-βs in various cell types has been investigated, their function in cartilage repair is as yet not fully understood. The effect of TGF-β3 in biological regulation of primary chondrocyte was investigated in this work. TGF-β3 provided fibroblastic morphology to chondrocytes and therefore overall reduction in cell proliferation was observed. The length of the cells supplemented with TGF-β3 were larger than the cells without TGF-β3 treatment. This was caused by the fibroblast like cells (dedifferentiated chondrocytes) which occupied larger areas compared to cells without TGF-β3 addition. The healing process of the model wound closure assay of chondrocyte multilayer was slowed down by TGF-β3, and this cytokine negatively affected the strength of chondrocyte adhesion to the cell culture surface.
    URI
    http://hdl.handle.net/10454/8908
    Version
    Accepted manuscript
    Citation
    Sefat F, Youseffi M, Khaghani SA, Soon CF and Javid F (2016) Effect of Transforming Growth Factor-β3 on mono and multilayer chondrocytes. Cytokine. 83: 118-126.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.cyto.2016.04.008
    Type
    Article
    Collections
    Engineering and Informatics Publications

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