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dc.contributor.authorKhurshid, Z.
dc.contributor.authorNajeeb, S.
dc.contributor.authorMali, M.
dc.contributor.authorMoin, S.F.
dc.contributor.authorRaza, S.Q.
dc.contributor.authorZohaib, S.
dc.contributor.authorSefat, Farshid
dc.contributor.authorZafar, M.S.
dc.date.accessioned2016-09-05T12:24:20Z
dc.date.available2016-09-05T12:24:20Z
dc.date.issued2016
dc.identifier.citationKhurshid Z, Najeeb S, Mali M et al (2016) Histatin peptides: Pharmacological functions and their applications in dentistry. Saudi Pharmaceutical Journal. Article in Press.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8907
dc.descriptionYesen_US
dc.description.abstractThere are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7–12 family members; corresponding to residues 12–24, 13–24, 12–25, 13–25, 5–11, and 5–12, respectively) for Histatin-3. However, Histatin-3 can be synthesized proteolytically from histatin 5 or 6. Due to their fungicidal response and high biocompatibility (little or no toxicity), these peptides can be considered as therapeutic agents with most probable applications for example, artificial saliva for denture wearers and salivary gland dysfunction conditions. The objectives of current article are to explore the human histatin peptides for its types, chemical and biological aspects. In addition, the potential for therapeutic bio-dental applications has been elaborated.en_US
dc.description.sponsorshipKing Saud Universityen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.jsps.2016.04.027en_US
dc.rights© 2016 The Authors. This is an open access article licensed under the Crative Commons CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.subjectSaliva; Oral cavity; Histatin; Antifungal activityen_US
dc.titleHistatin peptides: Pharmacological functions and their applications in dentistryen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-04-26
dc.date.application2016-05-04
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-07-25T14:57:59Z


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