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    Histatin peptides: Pharmacological functions and their applications in dentistry

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    Publication date
    2016
    Author
    Khurshid, Z.
    Najeeb, S.
    Mali, M.
    Moin, S.F.
    Raza, S.Q.
    Zohaib, S.
    Sefat, Farshid
    Zafar, M.S.
    Keyword
    Saliva; Oral cavity; Histatin; Antifungal activity
    Rights
    © 2016 The Authors. This is an open access article licensed under the Crative Commons CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7–12 family members; corresponding to residues 12–24, 13–24, 12–25, 13–25, 5–11, and 5–12, respectively) for Histatin-3. However, Histatin-3 can be synthesized proteolytically from histatin 5 or 6. Due to their fungicidal response and high biocompatibility (little or no toxicity), these peptides can be considered as therapeutic agents with most probable applications for example, artificial saliva for denture wearers and salivary gland dysfunction conditions. The objectives of current article are to explore the human histatin peptides for its types, chemical and biological aspects. In addition, the potential for therapeutic bio-dental applications has been elaborated.
    URI
    http://hdl.handle.net/10454/8907
    Version
    published version paper
    Citation
    Khurshid Z, Najeeb S, Mali M et al (2016) Histatin peptides: Pharmacological functions and their applications in dentistry. Saudi Pharmaceutical Journal. Article in Press.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.jsps.2016.04.027
    Type
    Article
    Collections
    Engineering and Informatics Publications

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