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dc.contributor.authorHogg, Ellen L.*
dc.contributor.authorMuller, Jurgen*
dc.contributor.authorCorrêa, Sonia A.L.*
dc.date.accessioned2016-08-04T14:05:33Z
dc.date.available2016-08-04T14:05:33Z
dc.date.issued2016-07
dc.identifier.citationHogg EL, Muller J and Correa SAL (2016) Does the MK2-dependent production of TNFα regulate mGluR-dependent synaptic plasticity? Current Neuropharmacology. 14(5): 474-480.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8746
dc.descriptionYesen_US
dc.description.abstractThe molecular mechanisms and signalling cascades that trigger the induction of group I metabotropic glutamate receptor (GI-mGluR)-dependent long-term depression (LTD) have been the subject of intensive investigation for nearly two decades. The generation of genetically modified animals has played a crucial role in elucidating the involvement of key molecules regulating the induction and maintenance of mGluR-LTD. In this review we will discuss the requirement of the newly discovered MAPKAPK-2 (MK2) and MAPKAPK-3 (MK3) signalling cascade in regulating GI-mGluR-LTD. Recently, it has been shown that the absence of MK2 impaired the induction of GI-mGluR-dependent LTD, an effect that is caused by reduced internalization of AMPA receptors (AMPAR). As the MK2 cascade directly regulates tumour necrosis factor alpha (TNFα) production, this review will examine the evidence that the release of TNFα acts to regulate glutamate receptor expression and therefore may play a functional role in the impairment of GI-mGluRdependent LTD and the cognitive deficits observed in MK2/3 double knockout animals. The strong links of increased TNFα production in both aging and neurodegenerative disease could implicate the action of MK2 in these processes.en_US
dc.description.sponsorshipThis work was supported by the BBSRC-BB/H018344/1 to S.A.L.C.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.2174/1570159X13666150624165939en_US
dc.rights© 2016 Bentham Science. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1570159X13666 150624165939en_US
dc.subjectAMPAR trafficking; Cognition; GI-mGluR-LTD; Hippocampus; MK2; p38 MAPK; TNFαen_US
dc.titleDoes the MK2-dependent production of TNFα regulate mGluR-dependent synaptic plasticity?en_US
dc.status.refereedYesen_US
dc.date.Accepted2015-05-26
dc.date.application2016-07-01
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-25T14:57:34Z


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