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    Equation to Line the Borders of the Folding–Unfolding Transition Diagram of Lysozyme

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    Publication date
    2016-07
    Author
    Mohammad, Mohammad A.
    Grimsey, Ian M.
    Forbes, Robert T.
    Keyword
    Biopharmaceuticals; Folding–unfolding transition diagrams; Denaturation; Lysozyme
    Rights
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.jpcb.6b01317
    Peer-Reviewed
    Yes
    
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    Abstract
    It is important for the formulators of biopharmaceuticals to predict the folding–unfolding transition of proteins. This enables them to process proteins under predetermined conditions, without denaturation. Depending on the apparent denaturation temperature (Tm) of lysozyme, we have derived an equation describing its folding–unfolding transition diagram. According to the water content and temperature, this diagram was divided into three different areas, namely, the area of the water-folded lysozyme phase, the area of the water-folded lysozyme phase and the bulk water phase, and the area of the denatured lysozyme phase. The water content controlled the appearance and intensity of the Raman band at ∼1787 cm–1 when lysozyme powders were thermally denatured at temperatures higher than Tm.
    URI
    http://hdl.handle.net/10454/8706
    Version
    Accepted Manuscript
    Citation
    Mohammad MA, Grimsey IM and Forbes RT (2016) Equation to line the borders of the folding-unfolding transition diagram of lysozyme. The Journal of Physical Chemistry B. 120(28): 6911-6916.
    Link to publisher’s version
    http://dx.doi.org/10.1021/acs.jpcb.6b01317
    Type
    Article
    Collections
    Life Sciences Publications

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