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dc.contributor.authorSoon, Chin Fhong*
dc.contributor.authorTee, K.S.*
dc.contributor.authorYouseffi, Mansour*
dc.contributor.authorDenyer, Morgan C.T.*
dc.date.accessioned2016-06-27T11:47:46Z
dc.date.available2016-06-27T11:47:46Z
dc.date.issued2015-01-05
dc.identifier.citationSoon CF, Tee KS, Youseffi M et al (2015) Tracking Traction Force Changes of Single Cells on the Liquid Crystal Surface. Biosensors. 5(1): 13-24.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8562
dc.descriptionYesen_US
dc.description.abstractCell migration is a key contributor to wound repair. This study presents findings indicating that the liquid crystal based cell traction force transducer (LCTFT) system can be used in conjunction with a bespoke cell traction force mapping (CTFM) software to monitor cell/surface traction forces from quiescent state in real time. In this study, time-lapse photo microscopy allowed cell induced deformations in liquid crystal coated substrates to be monitored and analyzed. The results indicated that the system could be used to monitor the generation of cell/surface forces in an initially quiescent cell, as it migrated over the culture substrate, via multiple points of contact between the cell and the surface. Future application of this system is the real-time assaying of the pharmacological effects of cytokines on the mechanics of cell migration.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.3390/bios5010013en_US
dc.rights© 2015 The Authors. This article is an Open Access article distributed under the terms and conditions of the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectLiquid crystals; Cell traction force transducer; Keratinocytes; Cell force mapping; Cell translocation; Cell migrationen_US
dc.titleTracking Traction Force Changes of Single Cells on the Liquid Crystal Surfaceen_US
dc.status.refereedyesen_US
dc.date.Accepted2014-12-02
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-25T13:29:14Z


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