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dc.contributor.authorMignon, Charles*
dc.contributor.authorBotchkareva, Natalia V.*
dc.contributor.authorUzunbajakava, N.E.*
dc.contributor.authorTobin, Desmond J.*
dc.date.accessioned2016-06-22T11:39:26Z
dc.date.available2016-06-22T11:39:26Z
dc.date.issued2016
dc.identifier.citationMignon C, Botchkareva NV, Uzunbajakava NE and Tobin DJ (2016) Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion. Experimental Dermatology. 25(10): 745-749.
dc.identifier.urihttp://hdl.handle.net/10454/8529
dc.descriptionYes
dc.description.abstractPhotobiomodulation is reported to positively influence hair regrowth, wound healing, skin rejuvenation, and psoriasis. Despite rapid translation of this science to commercial therapeutic solutions, significant gaps in our understanding of the underlying processes remain. The aim of this review was to seek greater clarity and rationality specifically for the selection of optical parameters for studies on hair regrowth and wound healing. Our investigation of 90 reports published between 1985-2015 revealed major inconsistencies in optical parameters selected for clinical applications. Moreover, poorly understood photoreceptors expressed in skin such as cytochrome c oxidase, cryptochromes, opsins, may trigger different molecular mechanisms. All this could explain the plethora of reported physiological effects of light. To derive parameters for optimal clinical efficacy of photobiomodulation, we recommend a more rational approach, underpinning clinical studies with research of molecular targets and pathways using well-defined biological model systems enabling easy translation of optical parameters from in vitro to in vivo. Furthermore, special attention needs to be paid when conducting studies for hair regrowth, aiming for double-blind, placebo-controlled randomized clinical trials as the gold standard for quantifying hair growth.
dc.description.sponsorshipEuropean Marie-Curie Actions Programme, Grant agreement no.: 607886
dc.language.isoen
dc.rights© 2016 Wiley Periodicals, Inc. This is the peer reviewed version of the article which has been published in final form at http://dx.doi.org/10.1111/exd.13035. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subjectPhotobiology
dc.subjectCryptochromes
dc.subjectOpsins
dc.subjectOptical parameters
dc.subjectSkin and hair regeneration
dc.titlePhotobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion.
dc.status.refereedYes
dc.date.Accepted15/04/2016
dc.date.application20/04/2016
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1111/exd.13035
dc.rights.licenseUnspecified
refterms.dateFOA2018-07-25T15:21:04Z
dc.openaccess.statusopenAccess


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