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dc.contributor.authorSnigdha, S.*
dc.contributor.authorNeill, Joanna C.*
dc.contributor.authorMcLean, Samantha*
dc.contributor.authorShemar, G.K.*
dc.contributor.authorCruise, L.*
dc.contributor.authorShahid, M.*
dc.contributor.authorHenry, B.*
dc.date.accessioned2016-06-13T13:02:14Z
dc.date.available2016-06-13T13:02:14Z
dc.date.issued2011-03
dc.identifier.citationSnigdha S, Neill JC, McLean SL, Shemar GK, Cruise L, Shahid M and Henry B (2010) Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain. Journal of Molecular Neuroscience. 43(3): 337-345.
dc.identifier.urihttp://hdl.handle.net/10454/8489
dc.descriptionYes
dc.description.abstractPhencyclidine (PCP), used to mimic certain aspects of schizophrenia, induces sexually dimorphic, cognitive deficits in rats. In this study, the effects of sub-chronic PCP on expression of brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of schizophrenia, have been evaluated in male and female rats. Male and female hooded-Lister rats received vehicle or PCP (n = 8 per group; 2 mg/kg i.p. twice daily for 7 days) and were tested in the attentional set shifting task prior to being sacrificed (6 weeks post-treatment). Levels of BDNF mRNA were measured in specific brain regions using in situ hybridisation. Male rats were less sensitive to PCP-induced deficits in the extra-dimensional shift stage of the attentional set shifting task compared to female rats. Quantitative analysis of brain regions demonstrated reduced BDNF levels in the medial prefrontal cortex (p < 0.05), motor cortex (p < 0.01), orbital cortex (p < 0.01), olfactory bulb (p < 0.05), retrosplenial cortex (p < 0.001), frontal cortex (p < 0.01), parietal cortex (p < 0.01), CA1 (p < 0.05) and polymorphic layer of dentate gyrus (p < 0.05) of the hippocampus and the central (p < 0.01), lateral (p < 0.05) and basolateral (p < 0.05) regions of the amygdaloid nucleus in female PCP-treated rats compared with controls. In contrast, BDNF was significantly reduced only in the orbital cortex and central amygdaloid region of male rats (p < 0.05). Results suggest that blockade of NMDA receptors by sub-chronic PCP administration has a long-lasting down-regulatory effect on BDNF mRNA expression in the female rat brain which may underlie some of the behavioural deficits observed post PCP administration.
dc.language.isoen
dc.rights© 2010 Humana Press. This work is licensed under a Creative Commons Attribution-Non-Commercial–No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/2.0/uk). This article is published with open access at Springerlink.com
dc.subjectPCP
dc.subjectBDNF
dc.subjectGender
dc.subjectSet-shifting
dc.subjectRats
dc.titlePhencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain
dc.status.refereedYes
dc.date.application2010-09-18
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.1007/s12031-010-9447-5
dc.rights.licenseCC-BY-NC-ND
refterms.dateFOA2018-07-25T15:19:55Z
dc.openaccess.statusopenAccess
dc.date.accepted2010-09-03


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