Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain
dc.contributor.author | Snigdha, S. | * |
dc.contributor.author | Neill, Joanna C. | * |
dc.contributor.author | McLean, Samantha | * |
dc.contributor.author | Shemar, G.K. | * |
dc.contributor.author | Cruise, L. | * |
dc.contributor.author | Shahid, M. | * |
dc.contributor.author | Henry, B. | * |
dc.date.accessioned | 2016-06-13T13:02:14Z | |
dc.date.available | 2016-06-13T13:02:14Z | |
dc.date.issued | 2011-03 | |
dc.identifier.citation | Snigdha S, Neill JC, McLean SL, Shemar GK, Cruise L, Shahid M and Henry B (2010) Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain. Journal of Molecular Neuroscience. 43(3): 337-345. | |
dc.identifier.uri | http://hdl.handle.net/10454/8489 | |
dc.description | Yes | |
dc.description.abstract | Phencyclidine (PCP), used to mimic certain aspects of schizophrenia, induces sexually dimorphic, cognitive deficits in rats. In this study, the effects of sub-chronic PCP on expression of brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of schizophrenia, have been evaluated in male and female rats. Male and female hooded-Lister rats received vehicle or PCP (n = 8 per group; 2 mg/kg i.p. twice daily for 7 days) and were tested in the attentional set shifting task prior to being sacrificed (6 weeks post-treatment). Levels of BDNF mRNA were measured in specific brain regions using in situ hybridisation. Male rats were less sensitive to PCP-induced deficits in the extra-dimensional shift stage of the attentional set shifting task compared to female rats. Quantitative analysis of brain regions demonstrated reduced BDNF levels in the medial prefrontal cortex (p < 0.05), motor cortex (p < 0.01), orbital cortex (p < 0.01), olfactory bulb (p < 0.05), retrosplenial cortex (p < 0.001), frontal cortex (p < 0.01), parietal cortex (p < 0.01), CA1 (p < 0.05) and polymorphic layer of dentate gyrus (p < 0.05) of the hippocampus and the central (p < 0.01), lateral (p < 0.05) and basolateral (p < 0.05) regions of the amygdaloid nucleus in female PCP-treated rats compared with controls. In contrast, BDNF was significantly reduced only in the orbital cortex and central amygdaloid region of male rats (p < 0.05). Results suggest that blockade of NMDA receptors by sub-chronic PCP administration has a long-lasting down-regulatory effect on BDNF mRNA expression in the female rat brain which may underlie some of the behavioural deficits observed post PCP administration. | |
dc.language.iso | en | |
dc.rights | © 2010 Humana Press. This work is licensed under a Creative Commons Attribution-Non-Commercial–No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/2.0/uk). This article is published with open access at Springerlink.com | |
dc.subject | PCP | |
dc.subject | BDNF | |
dc.subject | Gender | |
dc.subject | Set-shifting | |
dc.subject | Rats | |
dc.title | Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain | |
dc.status.refereed | Yes | |
dc.date.application | 2010-09-18 | |
dc.type | Article | |
dc.type.version | Published version | |
dc.identifier.doi | https://doi.org/10.1007/s12031-010-9447-5 | |
dc.rights.license | CC-BY-NC-ND | |
refterms.dateFOA | 2018-07-25T15:19:55Z | |
dc.openaccess.status | openAccess | |
dc.date.accepted | 2010-09-03 |