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dc.contributor.authorMcLean, Samantha L.
dc.contributor.authorIdris, Nagi F.
dc.contributor.authorWoolley, M.L.
dc.contributor.authorNeill, Joanna C.
dc.date.accessioned2016-06-13T09:19:14Z
dc.date.available2016-06-13T09:19:14Z
dc.date.issued2009-06
dc.identifier.citationMcLean SL, Idris NF, Woolley ML and Neill JC (2009) D1-like receptor activation improves PCP-induced cognitive deficits in animal models: implications for mechanisms of improved cognitive function in schizophrenia. European Neuropsychopharmacology. 19(6): 440-450.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8483
dc.descriptionYesen_US
dc.description.abstractPhencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D1-like receptor agonist, SKF-38393, to improve PCPinduced deficits in the novel object recognition (NOR) and operant reversal learning (RL) tasks. Rats received either sub-chronic PCP (2 mg/kg) or vehicle for 7 days, followed by a 7-day washout. Rats were either tested in NOR or the RL tasks. In NOR, vehicle rats successfully discriminated between novel and familiar objects, an effect abolished in PCP-treated rats. SKF-38393 (6 mg/kg) significantly ameliorated the PCP-induced deficit (Pb0.01) an effect significantly antagonised by SCH-23390 (0.05 mg/kg), a D1-like receptor antagonist (Pb0.01). In the RL task sub-chronic PCP significantly reduced performance in the reversal phase (Pb0.001); SKF-38393 (6.0 mg/kg) improved this PCPinduced deficit, an effect antagonised by SCH-23390 (Pb0.05). These results suggest a role for D1-like receptors in improvement of cognitive function in paradigms of relevance to schizophrenia.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.euroneuro.2009.01.009en_US
dc.rights© 2009 Elsevier B.V. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectD1 receptors; Schizophrenia; Recognition memory; Reversal learning; Female rat; Phencyclidineen_US
dc.titleD1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophreniaen_US
dc.status.refereedYesen_US
dc.date.Accepted2009-01-27
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-25T14:54:32Z


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