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    PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidineinduced cognitive deficit in the attentional set-shifting task in female rats

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    McLean_Journal_of_Psychopharmacology_2012.pdf (335.6Kb)
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    Publication date
    2012-09
    Author
    McLean, Samantha L.
    Idris, Nagi F.
    Grayson, Ben
    Gendle, D.F.
    Mackie, C.
    Lesage, A.S.
    Pemberton, D.J.
    Neill, Joanna C.
    Keyword
    α7 nACh receptors; Attentional set-shifting; Cognition; Female rat; Phencyclidine; Schizophrenia
    Rights
    The final, definitive version of this paper has been published in Journal of Psychopharmacology, 26(9) by SAGE Publications Ltd, All rights reserved. © 2012 SAGE Publications Ltd.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days’ washout. PCP-treated rats then received PNU-120596 (10mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p < 0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p < 0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors.
    URI
    http://hdl.handle.net/10454/8463
    Version
    Accepted Manuscript
    Citation
    McLean SL, Idris NF, Grayson B, Gendle DF, Mackie C, Lesage AS, Pemberton DJ and Neill JC (2012) PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. Journal of Psychopharmacology. 26(9): 1265-1270.
    Link to publisher’s version
    http://dx.doi.org/10.1177/0269881111431747
    Type
    Article
    Collections
    Life Sciences Publications

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