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dc.contributor.authorMcLean, Samantha L.*
dc.contributor.authorBlenkinsopp, Alison*
dc.contributor.authorBennett, M.I.*
dc.date.accessioned2016-06-07T09:40:53Z
dc.date.available2016-06-07T09:40:53Z
dc.date.issued2013
dc.identifier.citationMcLean SL, Blenkinsopp A and Bennett MI (2013) Using haloperidol as an anti-emetic in palliative care: informing practice through evidence from cancer treatment and post-operative contexts. Journal of Pain & Palliative Care Pharmacotherapy. 27(2): 132-135.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8462
dc.descriptionYesen_US
dc.description.abstractNausea and vomiting are common symptoms in palliative care. Haloperidol is often used as an antiemetic in this context, although direct evidence supporting this practice is limited. To evaluate the efficacy and clinical use of haloperidol as an antiemetic in nonpalliative care contexts to inform practice, the authors conducted a rapid review of (i) published evidence to supplement existing systematic reviews, and (ii) practical aspects affecting the use of haloperidol including formulations and doses that are commonly available internationally. In nausea and vomiting related to cancer treatment, haloperidol was superior to control in two small studies. In postoperative nausea and vomiting (PONV), two randomized controlledtrials found treatment with haloperidol comparable to ondansetron. In palliative care, an observational study found a complete response rate of 24% with haloperidol (one in four patients) which would be consistent with a number needed to treat (NNT) of 3 to 5 derived from PONV. There remains insufficient direct evidence to definitively support the use of haloperidol for the management of nausea and vomiting in palliative care. However, generalizing evidence from other clinical contexts may have some validity.en_US
dc.language.isoenen_US
dc.rights© 2013 Taylor & Francis. This is an Author's Original Manuscript of an article published by Taylor & Francis in Journal of Pain & Palliative Care Pharmacotherapy in 2013, available online at http://www.tandfonline.com/10.3109/15360288.2013.782937en_US
dc.subjectHaloperidol; Nausea; Palliative care; Postoperative nausea and vomiting; Vomitingen_US
dc.titleUsing haloperidol as an anti-emetic in palliative care: informing practice through evidence from cancer treatment and post-operative contextsen_US
dc.status.refereedYesen_US
dc.date.Accepted2013-03-09
dc.date.application2013-04-29
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.3109/15360288.2013.782937
refterms.dateFOA2018-07-25T15:18:55Z


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