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dc.contributor.authorWei, W.*
dc.contributor.authorZhang, X.*
dc.contributor.authorChen, Xianfeng*
dc.contributor.authorZhou, M.*
dc.contributor.authorXu, R.*
dc.contributor.authorZhang, X.*
dc.date.accessioned2016-05-17T08:09:14Z
dc.date.available2016-05-17T08:09:14Z
dc.date.issued2016-03
dc.identifier.citationWei W, Zhang X, Chen X, Zhou M, Xu R and Zhang X (2016) Smart surface coating of drug nanoparticles with cross- linkable polyethylene glycol for bio-responsive and highly efficient drug delivery. Nanoscale 8: 8118-8125.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8363
dc.descriptionYesen_US
dc.description.abstractMany drug molecules can be directly used as nanomedicine without the requirement of any inorganic or organic carriers such as silica and liposome nanostructures. This new type of carrier-free drug nanoparticles (NPs) has great potential in clinical treatment because of its ultra-high drug loading capacity and biodegradability. For practical applications, it is essential for such nanomedicine to possess robust stability and minimal premature release of therapeutic molecules during circulation in the blood stream. To meet this requirement, herein, we develop GSH-responsive and crosslinkable amphiphilic polyethylene glycol (PEG) molecules to modify carrier-free drug NPs. These PEG molecules can be cross-linked on the surface of the NPs to endow them with greater stability and the cross-link is sensitive to intracellular environment for bio-responsive drug release. With this elegant design, our experimental results show that the liberation of DOX from DOX-cross-linked PEG NPs is dramatically slower than that from DOX-non-cross-linked PEG NPs, and the DOX release profile can be controlled by tuning the concentration of the reducing agent to break the cross-link between PEG molecules. More importantly, in vivo studies reveal that the DOX-cross-linked PEG NPs exhibit favorable blood circulation half-life (>4 h) and intense accumulation in tumor areas, enabling effective anti-cancer therapy. We expect this work will provide a powerful strategy for stabilizing carrier-free nanomedicines and pave the way to their successful clinical applications in the future.en_US
dc.description.sponsorshipThe National Basic Research Program of China (2013CB933500, 2012CB932400), National Natural Science Foundation of China (61422403), Natural Science Foundation of Jiangsu Province (BK20131162), QingLan Project, Collaborative Innovation Center of Suzhou Nano Science and a Project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1039/c5nr09167een_US
dc.rights© 2016 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/)en_US
dc.subjectSmart surface coating; Polyethylene glycol; Nanoparticles; Drug delivery; Carrier-freeen_US
dc.titleSmart surface coating of drug nanoparticles with cross- linkable polyethylene glycol for bio-responsive and highly efficient drug deliveryen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-03-14
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-07-25T11:32:41Z


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