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dc.contributor.authorLi, Z.*
dc.contributor.authorZhao, X.*
dc.contributor.authorYe, L.*
dc.contributor.authorCoates, Philip D.*
dc.contributor.authorCaton-Rose, Philip D.*
dc.contributor.authorMartyn, Michael T.*
dc.date.accessioned2016-04-01T07:55:44Z
dc.date.available2016-04-01T07:55:44Z
dc.date.issued2015-01-15
dc.identifier.citationLi Z, Zhao X, Ye L, Coates PD, Caton-Rose PD and Martyn MT (2015) Structure and blood compatibility of highly oriented poly(l-lactic acid) chain extended by ethylene glycol diglycidyl ether. Polymer. 56: 523-534.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8040
dc.descriptionYesen_US
dc.description.abstractHighly-oriented poly(l-lactic acid) (PLLA) with fibrillar structure and micro-grooves was fabricated through solid hot drawing technology for further improving the mechanical properties and blood biocompatibility of PLLA as blood-contacting medical devices. In order to enhance the melt strength and thus obtain high orientation degree, PLLA was first chain extended with ethylene glycol diglycidyl ether (EGDE). The extending degree as high as 25.79 mol% can be obtained at 0.7 wt% EGDE content. The complex viscosity, storage and viscous modulus for chain extended PLLA were improved resulting from the enhancement of molecular entanglement, and consequently higher draw ratio can be achieved during the subsequent hot stretching. The tensile strength and modulus of PLLA were improved dramatically by stretching. The stress-induced crystallization of PLLA occurred during drawing. The interfacial tension (γs·blood) between PLLA surface and blood decreased by chain extension and molecular orientation, indicating the weakened interaction between bioactive substance in the blood and the surface of PLLA. Modification and orientation could significantly enhance the blood compatibility of PLLA by prolonging clotting time and decreasing hemolysis ratio, protein adsorption and platelet activation. The bionic character of oriented PLLA and its anti-coagulation mechanism were tried to be explored.en_US
dc.description.sponsorshipThis research was supported by National Natural Science Foundation of China (Grant No. 51303109)en_US
dc.language.isoenen_US
dc.rights© 2015 Elsevier Ltd. Full-text reproduced in accordance with the publisher’s self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.en_US
dc.subjectPoly (l-lactic acid) (PLLA)en_US
dc.subjectOrientation
dc.subjectBlood compatibility
dc.titleStructure and blood compatibility of highly oriented poly(l-lactic acid) chain extended by ethylene glycol diglycidyl etheren_US
dc.status.refereedYesen_US
dc.date.Accepted2014-11-14
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1016/j.polymer.2014.11.035
refterms.dateFOA2018-07-25T12:44:47Z


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