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    Structure and blood compatibility of highly oriented poly(l-lactic acid) chain extended by ethylene glycol diglycidyl ether

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    Publication date
    2015-01-15
    Author
    Li, Z.
    Zhao, X.
    Ye, L.
    Coates, Philip D.
    Caton-Rose, Philip D.
    Martyn, Michael T.
    Keyword
    Poly (l-lactic acid) (PLLA)
    Orientation
    Blood compatibility
    Rights
    © 2015 Elsevier Ltd. Full-text reproduced in accordance with the publisher’s self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
    Peer-Reviewed
    Yes
    
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    Abstract
    Highly-oriented poly(l-lactic acid) (PLLA) with fibrillar structure and micro-grooves was fabricated through solid hot drawing technology for further improving the mechanical properties and blood biocompatibility of PLLA as blood-contacting medical devices. In order to enhance the melt strength and thus obtain high orientation degree, PLLA was first chain extended with ethylene glycol diglycidyl ether (EGDE). The extending degree as high as 25.79 mol% can be obtained at 0.7 wt% EGDE content. The complex viscosity, storage and viscous modulus for chain extended PLLA were improved resulting from the enhancement of molecular entanglement, and consequently higher draw ratio can be achieved during the subsequent hot stretching. The tensile strength and modulus of PLLA were improved dramatically by stretching. The stress-induced crystallization of PLLA occurred during drawing. The interfacial tension (γs·blood) between PLLA surface and blood decreased by chain extension and molecular orientation, indicating the weakened interaction between bioactive substance in the blood and the surface of PLLA. Modification and orientation could significantly enhance the blood compatibility of PLLA by prolonging clotting time and decreasing hemolysis ratio, protein adsorption and platelet activation. The bionic character of oriented PLLA and its anti-coagulation mechanism were tried to be explored.
    URI
    http://hdl.handle.net/10454/8040
    Version
    Accepted Manuscript
    Citation
    Li Z, Zhao X, Ye L, Coates PD, Caton-Rose PD and Martyn MT (2015) Structure and blood compatibility of highly oriented poly(l-lactic acid) chain extended by ethylene glycol diglycidyl ether. Polymer. 56: 523-534.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.polymer.2014.11.035
    Type
    Article
    Collections
    Engineering and Informatics Publications

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