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dc.contributor.authorLi, Z.*
dc.contributor.authorYe, L.*
dc.contributor.authorZhao, X.*
dc.contributor.authorCoates, Philip D.*
dc.contributor.authorCaton-Rose, Philip D.*
dc.contributor.authorMartyn, Michael T.*
dc.date.accessioned2016-03-31T14:06:31Z
dc.date.available2016-03-31T14:06:31Z
dc.date.issued2016-03-25
dc.identifier.citationLi Z, Ye L, Zhao X et al (2016) High orientation of long chain branched poly (lactic acid) with enhanced blood compatibility and bionic structure. Journal of Biomedical Materials Research, Part A. 104(5): 1082-1089.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8031
dc.descriptionYesen_US
dc.description.abstractHighly-oriented poly (lactic acid) (PLA) with bionic micro-grooves was fabricated through solid hot drawing technology for further improving the mechanical properties and blood biocompatibility of PLA. In order to enhance the melt strength and thus obtain high orientation degree, long chain branched PLA (LCB-PLA) was prepared at first through a two-step ring-opening reaction during processing. Linear viscoelasticity combined with branch-on-branch (BOB) model was used to predict probable compositions and chain topologies of the products, and it was found that the molecular weight of PLA increased and topological structures with star like chain with three arms and tree-like chain with two generations formed during reactive processing, and consequently draw ratio as high as1200% can be achieved during the subsequent hot stretching. With the increase of draw ratio, the tensile strength and orientation degree of PLA increased dramatically. Long chain branching and orientation could significantly enhance the blood compatibility of PLA by prolonging clotting time and decreasing platelet activation. Micro-grooves can be observed on the surface of the oriented PLA which were similar to the intimal layer of blood vessel, and such bionic structure resulted from the formation of the oriented shish kebab-like crystals along the draw direction.en_US
dc.language.isoenen_US
dc.rights© 2016 Wiley Periodicals, Inc. Full-text reproduced in accordance with the publisher’s self-archiving policy. This is the peer reviewed version of the following article: Li Z, Ye L, Zhao X, Coates PD, Caton- Rose F and Martyn MT (2016) High orientation of long chain branched poly (lactic acid) with enhanced blood compatibility and bionic structure. Journal of Biomedical Materials Research, Part A. 104(5): 1082-1089, which has been published in final form at http://dx.doi.org/10.1002/jbm.a.35640. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/ WileyCDA/Section/id-820227.html#terms).en_US
dc.subjectPoly (lactic acid) (PLA)en_US
dc.subjectLong chain branching
dc.subjectMechanical properties
dc.subjectBlood compatibility
dc.subjectBionic character
dc.titleHigh orientation of long chain branched poly (lactic acid) with enhanced blood compatibility and bionic structureen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-12-30
dc.date.application2016-01-20
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1002/jbm.a.35640
refterms.dateFOA2018-07-25T12:44:36Z


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