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dc.contributor.authorLi, Z.*
dc.contributor.authorZhao, X.*
dc.contributor.authorYe, L.*
dc.contributor.authorCoates, Philip D.*
dc.contributor.authorCaton-Rose, Philip D.*
dc.contributor.authorMartyn, Michael T.*
dc.date.accessioned2016-03-31T13:36:10Z
dc.date.available2016-03-31T13:36:10Z
dc.date.issued2015-11-01
dc.identifier.citationLi Z, Zhao X, Ye L, Coates PD, Caton-Rose PD and Martyn MT (2015) Fibrillation of Chain branched Poly (lactic acid) with Improved Blood Compatibility and Bionic Structure. Chemical Engineering Journal. 279: 767-776.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8030
dc.descriptionYesen_US
dc.description.abstractHighly-oriented poly (lactic acid) (PLA) with bionic fibrillar structure and micro-grooves was fabricated through solid hot drawing technology for further improving the mechanical properties and blood biocompatibility of PLA as blood-contacting medical devices. In order to enhance the melt strength and thus obtain high orientation degree, PLA was first chain branched with pentaerythritol polyglycidyl ether (PGE). The branching degree as high as 12.69 mol% can be obtained at 0.5 wt% PGE content. The complex viscosity, elastic and viscous modulus for chain branched PLA were improved resulting from the enhancement of molecular entanglement, and consequently higher draw ratio can be achieved during the subsequent hot stretching. The stress-induced crystallization of PLA occurred during stretching, and the crystal structure of the oriented PLA can be attributed to the α′ crystalline form. The tensile strength and modulus of PLA were improved dramatically by drawing. Chain branching and orientation could significantly enhance the blood compatibility of PLA by prolonging clotting time and decreasing hemolysis ratio, protein adsorption and platelet activation. Fibrous structure as well as micro-grooves can be observed for the oriented PLA which were similar to intimal layer of blood vessel, and this bionic structure was considered to be beneficial to decrease the activation and/or adhesion of platelets.en_US
dc.language.isoenen_US
dc.rights© 2015 Elsevier B.V. Full-text reproduced in accordance with the publisher’s self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectPoly (lactic acid) (PLA)en_US
dc.subjectChain branching
dc.subjectFibrillation
dc.subjectMechanical properties
dc.subjectBlood compatibility
dc.subjectBionic character
dc.titleFibrillation of chain branched poly (lactic acid) with improved blood compatibility and bionic structureen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-05-25
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1016/j.cej.2015.05.082
refterms.dateFOA2018-07-25T12:44:26Z


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