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dc.contributor.authorXue, J.*
dc.contributor.authorHe, M.*
dc.contributor.authorLiu, H.*
dc.contributor.authorNiu, Y.*
dc.contributor.authorCrawford, A.*
dc.contributor.authorCoates, Philip D.*
dc.contributor.authorChen, D.*
dc.contributor.authorShi, R.*
dc.contributor.authorZhang, L.*
dc.date.accessioned2016-03-31T12:58:06Z
dc.date.available2016-03-31T12:58:06Z
dc.date.issued2014-11
dc.identifier.citationXue J, He M, Liu H et al (2014) Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes. Biomaterials. 35(34): 9395-9405.en_US
dc.identifier.urihttp://hdl.handle.net/10454/8028
dc.descriptionYesen_US
dc.description.abstractInfection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0, 1, 5, 10, 20, 30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%. Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies.en_US
dc.language.isoenen_US
dc.rights© 2014 Elsevier Ltd. Full-text reproduced in accordance with the publisher’s self-archiving policy. his manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectAnimals; Anti-infective agents; Biocompatible materials; Bone regeneration; Cell line; Cell proliferation; Drug delivery systems; Fusobacterium nucleatum; Gelatin; Guided tissue regeneration; Male; Membranes; Metronidazole; Mice; Nanofibers; Polyesters; Rabbits; Anti-infection; Drug delivery; Electrospinning; Guided tissue regenerationen_US
dc.titleDrug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranesen_US
dc.status.refereedYesen_US
dc.date.Accepted2014-07-28
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1016/j.biomaterials.2014.07.060
refterms.dateFOA2018-07-25T13:25:10Z


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