BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Engineering and Informatics
    • Engineering and Informatics Publications
    • View Item
    •   Bradford Scholars
    • Engineering and Informatics
    • Engineering and Informatics Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    coates_drug_loaded_homogeneous.pdf (2.334Mb)
    Download
    Publication date
    2014-11
    Author
    Xue, J.
    He, M.
    Liu, H.
    Niu, Y.
    Crawford, A.
    Coates, Philip D.
    Chen, D.
    Shi, R.
    Zhang, L.
    Keyword
    Animals; Anti-infective agents; Biocompatible materials; Bone regeneration; Cell line; Cell proliferation; Drug delivery systems; Fusobacterium nucleatum; Gelatin; Guided tissue regeneration; Male; Membranes; Metronidazole; Mice; Nanofibers; Polyesters; Rabbits; Anti-infection; Drug delivery; Electrospinning; Guided tissue regeneration
    Rights
    © 2014 Elsevier Ltd. Full-text reproduced in accordance with the publisher’s self-archiving policy. his manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Infection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0, 1, 5, 10, 20, 30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%. Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies.
    URI
    http://hdl.handle.net/10454/8028
    Version
    Accepted Manuscript
    Citation
    Xue J, He M, Liu H et al (2014) Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes. Biomaterials. 35(34): 9395-9405.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.biomaterials.2014.07.060
    Type
    Article
    Collections
    Engineering and Informatics Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.