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dc.contributor.authorLycett, D.*
dc.contributor.authorRyan, R.*
dc.contributor.authorFarley, A.*
dc.contributor.authorRoalfe, A.*
dc.contributor.authorMohammed, Mohammed A.*
dc.contributor.authorSzatkowski, L.*
dc.contributor.authorColeman, T.*
dc.contributor.authorMorris, R.*
dc.contributor.authorFarmer, A.*
dc.contributor.authorAveyard, P.*
dc.contributor.authorNichols, L.*
dc.date.accessioned2016-03-17T12:41:08Z
dc.date.available2016-03-17T12:41:08Z
dc.date.issued2015-06
dc.identifier.citationLycett D, Nichols L, Ryan R, Farley A, Roalfe A, Mohammed MA, Szatkowski L, Coleman T, Morris R, Farmer A and Aveyard P (2015) The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study.The Lancet Diabetes & Endocrinology, 3(6): 423–430.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7930
dc.descriptionnoen_US
dc.description.abstractBackground Smoking increases the risk of developing type 2 diabetes. However, several population studies also show a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk equates to that of never-smokers. Small cohort studies suggest diabetes control deteriorates temporarily during the first year after quitting. We examined whether or not quitting smoking was associated with altered diabetes control in a population study, for how long this association persisted, and whether or not this association was mediated by weight change. Methods We did a retrospective cohort study (Jan 1, 2005, to Dec 31, 2010) of adult smokers with type 2 diabetes using The Health Improvement Network (THIN), a large UK primary care database. We developed adjusted multilevel regression models to investigate the association between a quit event, smoking abstinence duration, change in HbA1c, and the mediating effect of weight change. Findings 10 692 adult smokers with type 2 diabetes were included. 3131 (29%) quit smoking and remained abstinent for at least 1 year. After adjustment for potential confounders, HbA1c increased by 0·21% (95% CI 0·17–0·25; p<0·001; [2·34 mmol/mol (95% CI 1·91–2·77)]) within the first year after quitting. HbA1c decreased as abstinence continued and became comparable to that of continual smokers after 3 years. This increase in HbA1c was not mediated by weight change. Interpretation In type 2 diabetes, smoking cessation is associated with deterioration in glycaemic control that lasts for 3 years and is unrelated to weight gain. At a population level, this temporary rise could increase microvascular complications.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/S2213-8587(15)00082-0en_US
dc.subjectSmoking cessation, Glycaemic control, Type 2 diabetes, THIN database cohort studyen_US
dc.titleThe association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort studyen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


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