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dc.contributor.authorWilliams, Jamie J.L.*
dc.contributor.authorMunro, K.M.A.*
dc.contributor.authorPalmer, Timothy M.*
dc.date.accessioned2016-03-16T10:13:29Z
dc.date.available2016-03-16T10:13:29Z
dc.date.issued2014-05-30
dc.identifier.citationWilliams JJL, Munro KMA and Palmer TM (2014) Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression. Cells. 3(2): 546-562.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7925
dc.descriptionYesen_US
dc.description.abstractThe realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3), its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.en_US
dc.description.sponsorshipBritish Heart Foundation; Chief Scientist's Office; NHS Greater Glasgow and Clyde Research Endowment Fund; BBSRCen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.3390/cells3020546en_US
dc.rights(c) 2014 The Authors. Full-text reproduced in accordance with the publisher's self-archiving policy. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/en_US
dc.subjectSOCS3; JAK; STAT; Inflammation; Ubiquitin; Proteasomal degradationen_US
dc.titleRole of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expressionen_US
dc.status.refereedYesen_US
dc.date.Accepted2014-05-04
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-07-25T13:24:12Z


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