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    Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression

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    Publication date
    2014-05-30
    Author
    Williams, Jamie J.L.
    Munro, K.M.A.
    Palmer, Timothy M.
    Keyword
    SOCS3; JAK; STAT; Inflammation; Ubiquitin; Proteasomal degradation
    Rights
    (c) 2014 The Authors. Full-text reproduced in accordance with the publisher's self-archiving policy. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/
    Peer-Reviewed
    Yes
    
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    Abstract
    The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3), its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.
    URI
    http://hdl.handle.net/10454/7925
    Version
    published version paper
    Citation
    Williams JJL, Munro KMA and Palmer TM (2014) Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression. Cells. 3(2): 546-562.
    Link to publisher’s version
    http://dx.doi.org/10.3390/cells3020546
    Type
    Article
    Collections
    Life Sciences Publications

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