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dc.contributor.authorRendeiro, C.*
dc.contributor.authorVauzour, D.*
dc.contributor.authorRattray, Marcus*
dc.contributor.authorWaffo-Téguo, P.*
dc.contributor.authorMérillon, J.M.*
dc.contributor.authorButler, L.T.*
dc.contributor.authorWilliams, C.M.*
dc.contributor.authorSpencer, J.P.E.*
dc.date.accessioned2016-02-23T16:31:22Z
dc.date.available2016-02-23T16:31:22Z
dc.date.issued2013-05-28
dc.identifier.citationRendeiro C, Vauzour D, Rattray M, Waffo-Téguo P, Mérillon JM, Butler LT, Williams CM and Spencer JP (2013) Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor. PLoS One, 8 (5): e63535.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7809
dc.descriptionyesen_US
dc.description.abstractEvidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w), results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively), to a similar extent to that following blueberry supplementation (p = 0.002). These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p<0.01), suggesting a common mechanism for the enhancement of memory. However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://doi.org/10.1371/journal.pone.0063535en_US
dc.rights© 2013 The Authors. Published Open Access by PLOS. Reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectFlavonoids; Flavanols; Anthocyanins; Spatial memory performance; Hippocampal Brain-Derived Neurotrophic Factoren_US
dc.titleDietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factoren_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-07-25T14:17:46Z


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