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    The effect of prior caffeine consumption on neuropsychological test performance: a placebo-controlled study

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    Publication date
    2016
    Author
    Walters, Elizabeth R.
    Lesk, Valerie E.
    Keyword
    Caffeine; Neuropsychological testing; Alzheimer's disease; Early diagnosis; Aging; Executive function; Placebo-controlled
    Rights
    (c) 2016 S. Karger AG. Full-text reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Background: The aim of this study was to investigate whether the prior consumption of 200mg of pure caffeine affected neuropsychological test scores in a group of elderly participants aged over 60 years. Method: Using a double blind placebo vs. caffeine design, participants were randomly assigned to receive 200mg of caffeine or placebo. A neuropsychological assessment testing the domains of general cognitive function, processing speed, semantic memory, episodic memory, executive function, working memory and short-term memory was carried out. Results: Significant interaction effects between age, caffeine and scores of executive function and processing speed were found; participants who had received caffeine showed a decline in performance with increasing age. This effect was not seen for participants who received placebo. Conclusion: The results highlight the need to consider and control prior caffeine consumption when scoring neuropsychological assessments in the elderly which is important for accuracy of diagnosis and corresponding normative data.
    URI
    http://hdl.handle.net/10454/7802
    Version
    final draft paper
    Citation
    Walters ER and Lesk VE (2016) The effect of prior caffeine consumption on neuropsychological test performance: a placebo-controlled study. Dementia and Geriatric Cognitive Disorders. Article in Press.
    Type
    Article
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    Social Sciences Publications

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