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    The Effect of Transforming Growth Factor Beta (TGF-β3) and Sanicle on Wound Healing.

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    Publication date
    2010-07
    Author
    Beggs, Clive B.
    Denyer, Morgan C.T.
    Lemmerz, A.
    Sefat, Farshid
    Wright, Colin W.
    Youseffi, Mansour
    Keyword
    3T3 Fibroblast Cell Culture; Growth Factor TGF-β3; Sanicle; Astringent; Anti-Scarring Effect; Wound healing.
    Peer-Reviewed
    n/a
    
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    Abstract
    There is evidence that both the herb Sanicle and the cytokine TGF- β3 can be beneficial in enhancing wound repair. In this study 3T3 fibroblast cells were cultured and the confluent monolayers were wounded (scarred) using a disposable plastic pipette. Various amounts of TGF-β3 (a growth factor) and Sanicle extract were applied to the cell monolayers. TGF-β3 was applied at concentrations of 50ng/ml, 5ng/ml, 500pg/ml, 50pg/ml and 5pg/ml to five different culture flasks with one additional flask acting as control. Sanicle was applied at concentrations of 100μg/ml, 10μg/ml, 1μg/ml, 100ng/ml and 10ng/ml with one additional flask as a control. The cells were imaged over a period of 20 hours with or without presence of TGF-β3 and Sanicle. The results indicated that although there were no significant increases in the rate of wound closure in relation to application of TGF-β3, there is an indication that TGF-β3 may enhance model wound closure at optimum working concentration between 5ng/ml and 50ng/ml. However, the sanicle extract did not stimulate enhanced repair of the model in vitro wound, but instead seemed to promote cell death along the wound margin. These results indicate that sanicle may be used in the care of wounds, but not as a growth promoter, but because it acts as an antibiotic agent, and possibly because it aids wound debridement.
    URI
    http://hdl.handle.net/10454/7502
    Version
    No full-text available in the repository
    Citation
    Beggs, C.B., Denyer, M.C.T., Lemmerz, A., Sefat, F., Wright, C. and Youseffi, M. (2010) The effect of transforming growth factor beta (TGF-β3) and sanicle on wound healing. Proceedings of the World Congress on Engineering, WCE 2010, June 30-July 2, London, 2010.
    Link to publisher’s version
    http://www.iaeng.org/publication/WCE2010/WCE2010_pp572-577.pdf
    Type
    Conference paper
    Collections
    Life Sciences Publications

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