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dc.contributor.authorAjaiyeoba, E.O.*
dc.contributor.authorOgbole, O.O.*
dc.contributor.authorAbiodun, O.O.*
dc.contributor.authorAshidi, J.S.*
dc.contributor.authorHoughton, P.J.*
dc.contributor.authorWright, Colin W.*
dc.date.accessioned2015-12-04T15:24:41Z
dc.date.available2015-12-04T15:24:41Z
dc.date.issued2013-02
dc.identifier.citationAjaiyeoba EO, Abiodun OO, Ashidi JS, Houghton PJ and Wright CW (2013) Cajachalcone: An antimalarial compound from Cajus cajan leaf extract. Journal of Parasitology Research. 54: 5188-5191.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7493
dc.descriptionnoen_US
dc.description.abstractCajanus cajan L, a member of the family Fabaceae, was identified from the Nigerian antimalarial ethnobotany as possessing antimalarial properties. The bioassay-guided fractionation of the crude methanol extract of C. cajan leaves was done in vitro using the multiresistant strain of Plasmodium falciparum (K1) in the parasite lactate dehydrogenase assay. Isolation of compound was achieved by a combination of chromatographic techniques, while the structure of the compound was elucidated by spectroscopy. This led to the identification of a cajachalcone, 2′,6′-dihydroxy-4-methoxy chalcone, as the biologically active constituent from the ethyl acetate fraction. Cajachalcone had an IC50 value of 2.0 μg/mL (7.4 μM) and could be a lead for anti-malarial drug discovery.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1155/2013/703781en_US
dc.subjectCajachalcone; Antimalarial compound; Cajanus cajan; Leaf extracten_US
dc.titleCajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extracten_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


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