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    Anticandida Agents from a Tanzanian Plant Albizia anthelmintica.

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    Publication date
    2015-08
    Author
    Runyoro, D.K.B.
    Joseph, C.C.
    Ngassapa, O.D.
    Darokar, M.P.
    Srivastava, S.K.
    Matee, M.I.N.
    Wright, Colin W.
    Keyword
    Anticandida agents; Albizia anthelmintica; Triterpenoid saponins; Echinocystic acid; Synergistic
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Candidiasis is one of the most frequent opportunistic infections in individuals with severe immunosupression and further development of resistance against the available antifungal drugs has created an alarming situation. This requires intensive drug discovery to develop new, more effective, affordable and accessible antifungal agents possessing novel modes of action. Albizia anthelmintica, which is ethno medically used to treat vaginal candidiasis in the Morogoro and coastal regions of Tanzania, on activity guided fractionation and subsequent purification resulted in the isolation and characterization of an isomer of methyl cyclitol (1) and six echinocystic acid saponins (2–7). Saponins 6 and 7 are new and being reported for the first time from nature. Among all the isolated compounds, 3-O-[α-L-arabinopyranosyl (1[RIGHTWARDS ARROW]2)][α-L-arabinopyranosyl (1[RIGHTWARDS ARROW]6)]-2-acetamido-2-deoxy-β-D-glucopyranosyl echinocystic acid (4), 3-O-[α-L-arabinopyranosyl (1[RIGHTWARDS ARROW]2)] [α-L-arabinopyranosyl (1[RIGHTWARDS ARROW]6)]-2-amino-2-deoxy-β-D-glucopyranosyl echinocystic acid (6) and 3-O-[β-D-glucopyranosyl (1[RIGHTWARDS ARROW]3)] [α-L-arabinopyranosyl (1[RIGHTWARDS ARROW]2)] [α-L-arabinopyranosyl (1[RIGHTWARDS ARROW]6)]-2-amino-2-deoxy-β-D-glucopyranosyl echinocystic acid (7) and their combinations were active against the various strains of C. albicans with MICs ranging from 12.5 to 125 μg/ml.
    URI
    http://hdl.handle.net/10454/7486
    Version
    No full-text available in the repository
    Citation
    Runyoro, D.B., Joseph, C.C., Ngassapa, O.D., Darokar, M.P., Srivastava, S.K., Matee, M.I.N. and Wright, C.W. (2015) Anticandida agents from a Tanzanian plant, Albizia anthelmintica. Journal of the Chinese Chemical Society 62: 669-674.
    Link to publisher’s version
    http://dx.doi.org/10.1002/jccs.201500161
    Type
    Article
    Collections
    Life Sciences Publications

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