Show simple item record

dc.contributor.authorDefaux, J.*
dc.contributor.authorSala, M.*
dc.contributor.authorFormosa, X.*
dc.contributor.authorGaldeano, C.*
dc.contributor.authorTaylor, M.C.*
dc.contributor.authorKelly, J.M.*
dc.contributor.authorWright, Colin W.*
dc.contributor.authorCamps, P.*
dc.contributor.authorMuñoz-Torrero, D.*
dc.contributor.authorAlobaid, Waleed A.A.*
dc.date.accessioned2015-11-03T13:22:57Z
dc.date.available2015-11-03T13:22:57Z
dc.date.issued2011
dc.identifier.citationDefaux J, Sala M, Formosa X et al (2011) Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. Bioorganic and Medicinal Chemistry. 19(5): 1702-1707.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7468
dc.descriptionNoen_US
dc.description.abstractA series of 19 huprines has been evaluated for their activity against cultured bloodstream forms of Trypanosoma brucei and Plasmodium falciparum. Moreover, cytotoxicity against rat myoblast L6 cells was assessed for selected huprines. All the tested huprines are moderately potent and selective trypanocidal agents, exhibiting IC50 values against T. brucei in the submicromolar to low micromolar range and selectivity indices for T. brucei over L6 cells of approximately 15, thus constituting interesting trypanocidal lead compounds. Two of these huprines were also found to be active against a chloroquine-resistant strain of P. falciparum, thus emerging as interesting trypanocidal–antiplasmodial dual acting compounds, but they exhibited little selectivity for P. falciparum over L6 cells.en_US
dc.language.isoenen_US
dc.subjectTrypanocidal agents; Antimalarial agents; 4-Aminoquinolines; Huprinesen_US
dc.titleHuprines as a new family of dual acting trypanocidal–antiplasmodial agentsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US
dc.identifier.doihttps://doi.org/10.1016/j.bmc.2011.01.028


This item appears in the following Collection(s)

Show simple item record