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dc.contributor.authorKulkarni, Chaitrali S.*
dc.contributor.authorWood, Clive*
dc.contributor.authorKelly, Adrian L.*
dc.contributor.authorGough, Timothy D.*
dc.contributor.authorBlagden, Nicholas*
dc.contributor.authorParadkar, Anant R.*
dc.date.accessioned2015-11-02T16:32:57Z
dc.date.available2015-11-02T16:32:57Z
dc.date.issued2015
dc.identifier.citationKulkarni C, Wood C, Kelly AL, Gough T, Blagden N, and Paradkar AR (2015) Stoichiometric control of co-crystal formation by solvent free continuous co-crystallization (SFCC). Crystal Growth & Design. 15(12): 5648–5651.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7460
dc.descriptionyesen_US
dc.description.abstractReproducible control of stoichiometry and difficulties in large scale production have been identified as two of the major challenges to commercial uptake of pharmaceutical co-crystals. The aim of this research was to extend the application of SFCC to control stoichiometry in caffeine: maleic acid co-crystals. Both 1:1 and 2:1 caffeine: maleic acid co-crystals were produced by control of the feedstock composition and process conditions. It was also observed that formation of 2:1 stoichiometry co-crystals involved formation of a 1:1 co-crystal which was subsequently transformed to 2:1 co-crystals. The investigation of stoichiometric transformation revealed that although 1:1 co-crystals could be converted into 2:1 form with addition of excess caffeine, the reverse was not possible in the presence of excess maleic acid. However, conversion from 2:1 into 1:1 was only achieved by melt seeding with the phase pure 1:1 co-crystals. This investigation demonstrates that stoichiometric control can be achieved by SFCC by control of parameters such as extrusion temperature.en_US
dc.language.isoenen_US
dc.rights© 2016 ACS. Reproduced in accordance with the publisher's self-archiving policy. This document is the author's version of a Submitted Work that was accepted for publication in Crystal Growth & Design. Copyright © American Chemical Society after peer review. To access the final edited and published work see http://dx.doi.org/10.1021/acs.cgd.5b00806en_US
dc.subjectCo-crystals, Stoichiometry, Caffeine, Maleic acid, Solvent free continuous co-crystallization (SFCC)en_US
dc.titleStoichiometric control of co-crystal formation by solvent free continuous co-crystallization (SFCC).en_US
dc.status.refereedyesen_US
dc.date.Accepted2015-10-29
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1021/acs.cgd.5b00806
refterms.dateFOA2018-07-25T14:12:51Z


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