Show simple item record

dc.contributor.authorSchallreuter, Karin U.*
dc.contributor.authorSalem, Mohamed M.A.*
dc.contributor.authorHasse, Sybille*
dc.contributor.authorRokos, Hartmut*
dc.date.accessioned2015-10-26T16:33:59Z
dc.date.available2015-10-26T16:33:59Z
dc.date.issued2011-02
dc.identifier.citationSchallreuter KU, Salem MAEL, Hasse S and Rokos H. (2011) The redox - biochemistry of human hair pigmentation. Pigment Cell & Melanoma Research, 24(1): 51-62.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7454
dc.descriptionnoen_US
dc.description.abstractThe biochemistry of hair pigmentation is a complex field involving a plethora of protein and peptide mechanisms. The in loco factory for melanin formation is the hair follicle melanocyte, but it is common knowledge that melanogenesis results from a fine tuned concerted interaction between the cells of the entire dermal papilla in the anagen hair follicle. The key enzyme is tyrosinase to initiate the active pigmentation machinery. Hence, an intricate understanding from transcription of mRNA to enzyme activity, including enzyme kinetics, substrate supply, optimal pH, cAMP signaling, is a must. Moreover, the role of reactive oxygen species on enzyme regulation and functionality needs to be taken into account. So far our knowledge on the entire hair cycle relies on the murine model of the C57BL/6 mouse. Whether this data can be translated into humans still needs to be shown. This article aims to focus on the effect of H2O2-redox homeostasis on hair follicle pigmentation via tyrosinase, its substrate supply and signal transduction as well as the role of methionine sulfoxide repair via methionine sulfoxide reductases A and B (MSRA and B).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1111/j.1755-148X.2010.00794.xen_US
dc.subjectH2O2-homeostasis; MSRA and B; Tyrosinase; 6-tetrahydro biopterin; POMC-peptides; Catecholamines; cAMP; Hair color; Gray; White hair; Pigmentationen_US
dc.titleThe redox - biochemistry of human hair pigmentation.en_US
dc.status.refereedyesen_US
dc.date.Accepted2010-10
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


This item appears in the following Collection(s)

Show simple item record