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dc.contributor.authorBotchkarev, Vladimir A.*
dc.contributor.authorGdula, Michal R.*
dc.contributor.authorMardaryev, Andrei N.*
dc.contributor.authorSharov, A.A.*
dc.contributor.authorFessing, Michael Y.*
dc.date.accessioned2015-10-20T09:13:07Z
dc.date.available2015-10-20T09:13:07Z
dc.date.issued2012-11
dc.identifier.citationBotchkarev VA, Gdula MR, Mardaryev AN, Sharov AA and Fessing MY (2012) Epigenetic Regulation of Gene Expression in Keratinocytes. Journal of Investigative Dermatologoy, 132 (11): 2505–2521.
dc.identifier.urihttp://hdl.handle.net/10454/7433
dc.descriptionNo
dc.description.abstractThe nucleus is a complex and highly compartmentalized organelle, which undergoes major organization changes during cell differentiation, allowing cells to become specialized and fulfill their functions. During terminal differentiation of the epidermal keratinocytes, the nucleus undergoes a programmed transformation from active status, associated with execution of the genetic programs of cornification and epidermal barrier formation, to a fully inactive condition and becomes a part of the keratinized cells of the cornified layer. Tremendous progress achieved within the past two decades in understanding the biology of the nucleus and epigenetic mechanisms controlling gene expression allowed defining several levels in the regulation of cell differentiation–associated gene expression programs, including an accessibility of the gene regulatory regions to DNA–protein interactions, covalent DNA and histone modifications, and ATP-dependent chromatin remodeling, as well as higher-order chromatin remodeling and nuclear compartmentalization of the genes and transcription machinery. Here, we integrate our current knowledge of the mechanisms controlling gene expression during terminal keratinocyte differentiation with distinct levels of chromatin organization and remodeling. We also propose directions to further explore the role of epigenetic mechanisms and their interactions with other regulatory systems in the control of keratinocyte differentiation in normal and diseased skin.
dc.language.isoen
dc.subjectKeratinocytes
dc.subjectGene Expression
dc.subjectEpigenetic Regulation
dc.subjectNucleus
dc.subjectTerminal keratinocyte differentiation
dc.subjectChromatin organization
dc.titleEpigenetic Regulation of Gene Expression in Keratinocytes
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1038/jid.2012.182
dc.openaccess.statusclosedAccess


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