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    IL-36γ (IL-1F9) Is a Biomarker for Psoriasis Skin Lesions.

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    Publication date
    2015-01
    Author
    D'Erme, A.M.
    Wilsmann-Theis, D.
    Wagenpfeil, J.
    Hölzel, M.
    Sternberg, S.
    Wittmann, Miriam
    Peters, B.
    Bosio, A.
    Bieber, T.
    Wenzel, J.
    Keyword
    Psoriasis; Skin lesions; Biomarkers; Inflamatory skin diseases
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    In recent years, different genes and proteins have been highlighted as potential biomarkers for psoriasis, one of the most common inflammatory skin diseases worldwide. However, most of these markers are not only psoriasis-specific but also found in other inflammatory disorders. We performed an unsupervised cluster analysis of gene expression profiles in 150 psoriasis patients and other inflammatory skin diseases (atopic dermatitis, lichen planus, contact eczema, and healthy controls). We identified a cluster of IL-17/tumor necrosis factor-α (TNFα)-associated genes specifically expressed in psoriasis, among which IL-36γ was the most outstanding marker. In subsequent immunohistological analyses, IL-36γ was confirmed to be expressed in psoriasis lesions only. IL-36γ peripheral blood serum levels were found to be closely associated with disease activity, and they decreased after anti-TNFα-treatment. Furthermore, IL-36γ immunohistochemistry was found to be a helpful marker in the histological differential diagnosis between psoriasis and eczema in diagnostically challenging cases. These features highlight IL-36γ as a valuable biomarker in psoriasis patients, both for diagnostic purposes and measurement of disease activity during the clinical course. Furthermore, IL-36γ might also provide a future drug target, because of its potential amplifier role in TNFα- and IL-17 pathways in psoriatic skin inflammation.
    URI
    http://hdl.handle.net/10454/7426
    Version
    No full-text available in the repository
    Citation
    D'Erme AM, Wilsmann-Theis D, Wagenpfeil J, Hölzel M, Ferring-Schmitt S, Sternberg S, Wittmann M, Peters B, Bosio A, Bieber T and Wenzel J. (2015) IL-36γ (IL-1F9) Is a Biomarker for Psoriasis Skin Lesions. Journal of Investigative Dermatology, 135 (4):1025-32.
    Link to publisher’s version
    http://dx.doi.org/10.1038/jid.2014.532
    Type
    Article
    Collections
    Life Sciences Publications

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