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    IL-33 impacts on the skin barrier by downregulating the expression of filaggrin

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    Publication date
    2015-06
    Author
    Seltmann, J.
    Roesner, L.M.
    Hesler, F-W. von
    Wittmann, Miriam
    Werfel, T.
    Keyword
    IL-33; Cytokines; Skin barrier; Filaggrin; Atopic dermatitis; AD
    Peer-Reviewed
    n/a
    
    Metadata
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    Abstract
    IL-33 is a member of the IL-1 family of cytokines that is constitutively expressed in healthy skin and was found to be increased in the skin of patients with atopic dermatitis (AD). Because it can be released after tissue damage or physical stress including scratching of the skin,1 it has been classified as an alarmin concerned with alerting the immune system.2 It enhances TH2 responses by inducing IL-5 and IL-13 as well as TH1 responses via upregulation of IFN-γ. Keratinocytes are known producer cells of IL-33 and also express the receptor complex consisting of ST2 and IL-1RAcP on their surface. The aim of this study was to investigate the effect of IL-33 on keratinocytes, skin biopsies, and living skin equivalents with regard to the regulation of the skin barrier molecule filaggrin (FLG).
    URI
    http://hdl.handle.net/10454/7425
    Version
    No full-text available in the repository
    Citation
    Seltmann J, Roesner LM, Hesler F-W von, Wittmann M and Werfel T (2015) IL-33 impacts on the skin barrier by downregulating the expression of filaggrin [Letter to the editor]. Journal of Allergy and Clinical Immunology. 135(6): 1659- 1661.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.jaci.2015.01.048
    Type
    Article
    Collections
    Life Sciences Publications

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