Assessment of cognitive function across pregnancy using CANTAB: A longitudinal study
dc.contributor.author | Farrar, D. | * |
dc.contributor.author | Tuffnell, D.J. | * |
dc.contributor.author | Neill, D. | * |
dc.contributor.author | Scally, Andy J. | * |
dc.contributor.author | Marshall, Kay M. | * |
dc.date.accessioned | 2015-09-30T14:05:44Z | |
dc.date.available | 2015-09-30T14:05:44Z | |
dc.date.issued | 2014-02 | |
dc.identifier.citation | Farrar D, Tuffnell D, Neill J, Scally AJ and Marshall K (2014) Assessment of cognitive function across pregnancy using CANTAB: A longitudinal study. Brain and Cognition. 84(1): 76-84. | |
dc.identifier.uri | http://hdl.handle.net/10454/7412 | |
dc.description | No | |
dc.description.abstract | Significant changes in endogenous plasma hormone levels are required to sustain pregnancy which provides a unique opportunity to study their effect on cognitive function. Four carefully selected tests from the Cambridge Neuropsychological Automated Test Battery (CANTAB) were administered to assess the cognitive function of a group of 23 women during each trimester of pregnancy and at three months following birth. Test scores were compared with a control group of 24 non-pregnant women. The Edinburgh Postnatal Depression Scale was administered to assess anxiety and risk of depression. The National Adult Reading Test (NART) was used as a measure of verbal intelligence. Plasma hormone levels were measured at each time-point. The pregnant group scored significantly lower than the control group on the Spatial Recognition Memory (SRM) test at the second trimester and postpartum assessments (p ⩽ 0.004). A significant pregnant group-time interaction (p = 0.005) for SRM performance was demonstrated. Compared to their first trimester assessment, the pregnant group scored on average 11.7% less on each subsequent SRM test. The pregnant group reported more symptoms of anxiety and depression compared to the control group (EPDS-4 point increase in mean score at each assessment, p = 0.002). There were no plasma hormone levels and test score associations identified. | |
dc.language.iso | en | en |
dc.subject | CANTAB | |
dc.subject | Spatial recognition memory | |
dc.subject | Cognition | |
dc.subject | Pregnancy | |
dc.subject | Plasma hormones | |
dc.title | Assessment of cognitive function across pregnancy using CANTAB: A longitudinal study | |
dc.status.refereed | Yes | |
dc.type | Article | |
dc.type.version | No full-text in the repository | |
dc.identifier.doi | https://doi.org/10.1016/j.bandc.2013.11.003 | |
dc.openaccess.status | closedAccess | |
dc.date.accepted | 2013-11-06 |