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dc.contributor.authorFarrar, D.*
dc.contributor.authorTuffnell, D.J.*
dc.contributor.authorNeill, D.*
dc.contributor.authorScally, Andy J.*
dc.contributor.authorMarshall, Kay M.*
dc.date.accessioned2015-09-30T14:05:44Z
dc.date.available2015-09-30T14:05:44Z
dc.date.issued2014-02
dc.identifier.citationFarrar D, Tuffnell D, Neill J, Scally AJ and Marshall K (2014) Assessment of cognitive function across pregnancy using CANTAB: A longitudinal study. Brain and Cognition. 84(1): 76–84.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7412
dc.descriptionnoen_US
dc.description.abstractSignificant changes in endogenous plasma hormone levels are required to sustain pregnancy which provides a unique opportunity to study their effect on cognitive function. Four carefully selected tests from the Cambridge Neuropsychological Automated Test Battery (CANTAB) were administered to assess the cognitive function of a group of 23 women during each trimester of pregnancy and at three months following birth. Test scores were compared with a control group of 24 non-pregnant women. The Edinburgh Postnatal Depression Scale was administered to assess anxiety and risk of depression. The National Adult Reading Test (NART) was used as a measure of verbal intelligence. Plasma hormone levels were measured at each time-point. The pregnant group scored significantly lower than the control group on the Spatial Recognition Memory (SRM) test at the second trimester and postpartum assessments (p ⩽ 0.004). A significant pregnant group-time interaction (p = 0.005) for SRM performance was demonstrated. Compared to their first trimester assessment, the pregnant group scored on average 11.7% less on each subsequent SRM test. The pregnant group reported more symptoms of anxiety and depression compared to the control group (EPDS-4 point increase in mean score at each assessment, p = 0.002). There were no plasma hormone levels and test score associations identified.en_US
dc.language.isoenen_US
dc.subjectCANTAB; Spatial recognition memory; Cognition; Pregnancy; Plasma hormonesen_US
dc.titleAssessment of cognitive function across pregnancy using CANTAB: A longitudinal studyen_US
dc.status.refereedyesen_US
dc.date.Accepted2013-11-06
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US
dc.identifier.doihttps://doi.org/10.1016/j.bandc.2013.11.003


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