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    Associations of Circulating Calcium and 25-Hydroxyvitamin D With Glucose Metabolism in Pregnancy: A Cross-Sectional Study in European and South Asian Women

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    Publication date
    2014-03
    Author
    Whitelaw, D.C.
    Scally, Andy J.
    Tuffnell, D.J.
    Davies, T.J.
    Fraser, W.D.
    Bhopal, R.S.
    Wright, J.
    Lawlor, D.A.
    Keyword
    Pregnancy; 25-Hydroxyvitamin D; Vitamin-D status; Glucose metabolism; Insulin levels; Circulating calcium; European women; South Asian women
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Background: Vitamin D deficiency is thought to impair insulin action and glucose metabolism; however, previous studies have not examined ethnic differences or the influence of calcium and parathyroid hormone. We investigated this in a cohort of predominantly white European and south Asian women during pregnancy. Methods: In this cross-sectional study from an urban population in northern England (53.8°N), 1467 women were recruited when undergoing glucose tolerance testing (75 g oral glucose tolerance test) at 26 weeks' gestation. Results: Gestational diabetes mellitus (GDM) was diagnosed in 137 women (9.3%). Median 25-hydroxyvitamin D concentration for the study population was 9.3 ng/mL (interquartile range 5.2, 16.9) and was higher in European [15.2 ng/mL (10.7, 23.5)] than in south Asian women [5.9 ng/mL (3.9, 9.4), P < .001]. After appropriate adjustment for confounders, 25-hydroxyvitamin D showed a weak inverse association with fasting plasma glucose (FPG; mean difference 1.0% per 1 SD; the ratio of geometric means (RGM) 0.99, 95% confidence interval (CI) 0.98, 1.00), and PTH was weakly associated with FPG (RGM 1.01, 95% CI 1.00, 1.02), but neither was associated with fasting insulin, postchallenge glucose, or GDM. Serum calcium (albumin adjusted) was strongly associated with fasting insulin (RGM 1.06; 95% CI 1.03, 1.08), postchallenge glucose (RGM 1.03, 95% CI 1.01, 1.04), and GDM (odds ratio 1.33, 95% CI 1.06, 1.66) but not with FPG. Associations were similar in European and south Asian women. Conclusions: These findings do not indicate any important association between vitamin D status and glucose tolerance in pregnancy. Relationships between circulating calcium and glucose metabolism warrant further investigation.
    URI
    http://hdl.handle.net/10454/7407
    Version
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    Citation
    Whitelaw DC, Scally AJ, Tuffnell DJ , Davies TJ, Fraser WD, Bhopal RS, Wright J and Lawlor DA (2014) Associations of Circulating Calcium and 25-Hydroxyvitamin D With Glucose Metabolism in Pregnancy: A Cross-Sectional Study in European and South Asian Women. Journal of Clinical Endocrinology and Metabolism. 99(3): 938–946.
    Link to publisher’s version
    http://dx.doi.org/10.1210/jc.2013-2896
    Type
    Article
    Collections
    Health Studies Publications

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