Lipidomics applications in health, disease and nutrition research
Abstract
The structural and functional diversity of lipids accounts for their involvement into a wide range of homeostatic processes and disease states, including lifestyle-related diseases as well as genetic conditions. Challenges presented by this diversity have been addressed to a great extent by the development of lipidomics, a platform that makes possible the detailed profiling and characterisation of lipid species present in any cell, organelle, tissue or body fluid, and allows for a wider appreciation of the biological role of lipid networks. Progress in the field of lipidomics has been greatly facilitated by recent advances in MS and includes a range of analytical platforms supporting applications spanning from qualitative and quantitative assessment of multiple species to lipid imaging. Here we review these MS techniques currently in routine use in lipidomics, alongside with new ones that have started making an impact in the field. Recent applications in health, disease and nutrition-related questions will also be discussed with a view to convey the importance of lipidomics contributions to biosciences and food technology.Version
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Murphy SA and Nicolaou A ( 2013) Lipidomics applications in health, disease and nutrition research. Molecular Nutrition and Food Research. 57(8): 1336-1346.Link to Version of Record
https://doi.org/10.1002/mnfr.201200863Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1002/mnfr.201200863