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    Hepatic Arterial Infusion with Oxaliplatin and 5-FU/Folinic Acid for Advanced Biliary Tract Cancer: A Phase II Study.

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    Publication date
    2013-08
    Author
    Sinn, M.
    Nicolaou, Anna
    Gebauer, B.
    Podrabsky, P.
    Seehofer, D.
    Ricke, J.
    Dörken, B.
    Riess, H.
    Hildebrandt, B.
    Keyword
    Hepatic arterial infusion (HAI); Oxaliplatin; 5-FU/Folinic Acid; Advanced biliary tract cancer
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Background Effective and tolerable chemotherapy with gemcitabine and cisplatin for advanced biliary tract cancer (BTC) has been established recently. However, overall prognosis is still poor, and additional therapeutic approaches are needed for patients with locally advanced, irresectable and/or pretreated tumors. Hepatic arterial infusion (HAI) of chemotherapy represents a safe and well-established treatment modality, but data on its use in patients with BTC are still sparse. Methods Patients with irresectable BTC predominant to the liver were included in a prospective, open phase II study investigating HAI provided through interventionally implanted port catheters. Intraarterial chemotherapy consisted of biweekly oxaliplatin (O) 85 mg/m2 and folinic acid (F) 170 mg/m2 with 5-FU (F) 600 mg/m2. Results Between 2004 and 2010, 37 patients were enrolled. A total of 432 cycles of HAI were applied with a median of 9 (range 1–46) cycles. Objective response rate was 16 %, and tumor control was achieved in 24 of 37 (65 %) patients. Median progression-free survival was 6.5 months (range 0.5–26.0; 95 % CI 4.3–8.7), median overall survival was 13.5 (range 0.9–50.7; 95 % CI 11.1–15.9) months. The most frequent adverse event was sensory neuropathy grade 1/2 in 10/14 patients. Conclusions Using a minimal invasive technique, repetitive HAI with OFF is feasible and results in clinically relevant tumor control with low toxicity in patients with liver predominant advanced BTC.
    URI
    http://hdl.handle.net/10454/7248
    Version
    No full-text available in the repository
    Citation
    Sinn M, Nicolaou A, Gebauer B, Podrabsky P, Seehofer D, Ricke J, Dörken B, Riess H and Hildebrandt B (2013) Hepatic Arterial Infusion with Oxaliplatin and 5-FU/Folinic Acid for Advanced Biliary Tract Cancer: A Phase II Study. Digestive Diseases and Sciences 58 (8): 2399-2405.
    Link to publisher’s version
    http://dx.doi.org/10.1007/s10620-013-2624-y
    Type
    Article
    Collections
    Life Sciences Publications

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