Show simple item record

dc.contributor.authorRamirez, Y.P.*
dc.contributor.authorWeatherbee, J.L.*
dc.contributor.authorWheelhouse, Richard T.*
dc.contributor.authorRoss, A.H.*
dc.date.accessioned2015-06-09T08:57:47Z
dc.date.available2015-06-09T08:57:47Z
dc.date.issued2013-11-25
dc.identifier.citationRamirez YP, Weatherbee JL, Wheelhouse RT and Ross AH (2013) Glioblastoma Multiforme Therapy and Mechanisms of Resistance. Pharmaceuticals. 6(12): 1475-1506.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7240
dc.descriptionYesen_US
dc.description.abstractGlioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The current standard of care, comprised of surgical resection followed by radiation and the chemotherapeutic agent temozolomide, only provides patients with a 12–14 month survival period post-diagnosis. Long-term survival for GBM patients remains uncommon as cells with intrinsic or acquired resistance to treatment repopulate the tumor. In this review we will describe the mechanisms of resistance, and how they may be overcome to improve the survival of GBM patients by implementing novel chemotherapy drugs, new drug combinations and new approaches relating to DNA damage, angiogenesis and autophagy.en_US
dc.language.isoenen_US
dc.rights© 2013 Multidisciplinary Digital Publishing Institute. This is an open access article distributed under the Creative Commons Attribution License (CC-BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectAngiogenesis; Autophagy; Imidazotetrazine; MGMT; DNA repair; Temozolomide; Cancer stem cellsen_US
dc.titleGlioblastoma Multiforme Therapy and Mechanisms of Resistanceen_US
dc.status.refereedYesen_US
dc.date.Accepted2013-11-12
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/ 10.3390/ph6121475
refterms.dateFOA2018-07-25T10:54:54Z


Item file(s)

Thumbnail
Name:
wheelhouse_glioblastoma_multif ...
Size:
726.3Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record