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    Glioblastoma Multiforme Therapy and Mechanisms of Resistance

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    wheelhouse_glioblastoma_multiforme_therapy_pharmaceuticals.pdf (726.3Kb)
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    Publication date
    2013-11-25
    Author
    Ramirez, Y.P.
    Weatherbee, J.L.
    Wheelhouse, Richard T.
    Ross, A.H.
    Keyword
    Angiogenesis; Autophagy; Imidazotetrazine; MGMT; DNA repair; Temozolomide; Cancer stem cells
    Rights
    © 2013 Multidisciplinary Digital Publishing Institute. This is an open access article distributed under the Creative Commons Attribution License (CC-BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Peer-Reviewed
    Yes
    
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    Abstract
    Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The current standard of care, comprised of surgical resection followed by radiation and the chemotherapeutic agent temozolomide, only provides patients with a 12–14 month survival period post-diagnosis. Long-term survival for GBM patients remains uncommon as cells with intrinsic or acquired resistance to treatment repopulate the tumor. In this review we will describe the mechanisms of resistance, and how they may be overcome to improve the survival of GBM patients by implementing novel chemotherapy drugs, new drug combinations and new approaches relating to DNA damage, angiogenesis and autophagy.
    URI
    http://hdl.handle.net/10454/7240
    Version
    Accepted Manuscript
    Citation
    Ramirez YP, Weatherbee JL, Wheelhouse RT and Ross AH (2013) Glioblastoma Multiforme Therapy and Mechanisms of Resistance. Pharmaceuticals. 6(12): 1475-1506.
    Link to publisher’s version
    http://dx.doi.org/ 10.3390/ph6121475
    Type
    Article
    Collections
    Life Sciences Publications

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