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    Pathobiology of chemotherapy-induced hair loss.

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    Publication date
    2013
    Author
    Paus, R.
    Haslam, I.S.
    Sharov, A.A.
    Botchkarev, Vladimir A.
    Keyword
    Hair loss; Chemotherapy; Alopecia;
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Hair loss can be a psychologically devastating adverse effect of chemotherapy, but satisfactory management strategies for chemotherapy-induced alopecia remain elusive. In this Review we focus on the complex pathobiology of this side-effect. We discuss the clinical features and current management approaches, then draw upon evidence from mouse models and human hair-follicle organ-culture studies to explore the main pathobiology principles and explain why chemotherapy-induced alopecia is so challenging to manage. P53-dependent apoptosis of hair-matrix keratinocytes and chemotherapy-induced hair-cycle abnormalities, driven by the dystrophic anagen or dystrophic catagen pathway, play important parts in the degree of hair-follicle damage, alopecia phenotype, and hair-regrowth pattern. Additionally, the degree of hair-follicle stem-cell damage determines whether chemotherapy-induced alopecia is reversible. We highlight the need for carefully designed preclinical research models to generate novel, clinically relevant pointers to how this condition may be overcome.
    URI
    http://hdl.handle.net/10454/7224
    Version
    No full-text available in the repository
    Citation
    Paus R, Haslam IS, Sharov AA and Botchkarev VA. (2013) Pathobiology of chemotherapy-induced hair loss. Lancet Oncology, 14 (2): e50-9.
    Link to publisher’s version
    http://dx.doi.org/10.1016/S1470-2045(12)70553-3
    Type
    Article
    Collections
    Life Sciences Publications

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